Genetic Interaction Search Results

• Genetic Interaction

the number of plants displaying the As2 phenotype was significantly higher than that of As1 individuals, suggesting an epi- static effect of as2 mutations upon as1, which yields a 9:4:3 phenotypic segregation

Serrano-Cartagena J, Robles P, Ponce MR, Micol JL - Genetic analysis of leaf form mutants from the Arabidopsis Information Service collection

• Genetic Interaction

icu2/icu2;ag-1/ag-1 ... leaf lamina normalized

Serrano-Cartagena J, Candela H, Robles P, Ponce MR, Pérez-Pérez JM, Piqueras P, Micol JL - Genetic analysis of incurvata mutants reveals three independent genetic operations at work in Arabidopsis leaf morphogenesis

• Genetic Interaction

hst-5/hst-5;icu4-1/icu4-1 rosettes ... appeared to be very small ... synergistic

Serrano-Cartagena J, Candela H, Robles P, Ponce MR, Pérez-Pérez JM, Piqueras P, Micol JL - Genetic analysis of incurvata mutants reveals three independent genetic operations at work in Arabidopsis leaf morphogenesis

• Genetic Interaction

clf-18/clf18; ag-1/ag-1 ... leaf lamina normalized

Serrano-Cartagena J, Candela H, Robles P, Ponce MR, Pérez-Pérez JM, Piqueras P, Micol JL - Genetic analysis of incurvata mutants reveals three independent genetic operations at work in Arabidopsis leaf morphogenesis

• Genetic Interaction

clf-18/clf-18;icu2/ icu2 double mutants were much smaller ... The phenotype of these double-mutant individuals was considered to be synergistic

Serrano-Cartagena J, Candela H, Robles P, Ponce MR, Pérez-Pérez JM, Piqueras P, Micol JL - Genetic analysis of incurvata mutants reveals three independent genetic operations at work in Arabidopsis leaf morphogenesis

• Genetic Interaction

icu2/icu2;ag-1/ag-1 plants also displayed a leaf marginal configuration slightly different from that of the wild type

Serrano-Cartagena J, Candela H, Robles P, Ponce MR, Pérez-Pérez JM, Piqueras P, Micol JL - Genetic analysis of incurvata mutants reveals three independent genetic operations at work in Arabidopsis leaf morphogenesis

• Genetic Interaction

icu2/icu2;icu5/icu5 ... interpreted as a result of additivity

Serrano-Cartagena J, Candela H, Robles P, Ponce MR, Pérez-Pérez JM, Piqueras P, Micol JL - Genetic analysis of incurvata mutants reveals three independent genetic operations at work in Arabidopsis leaf morphogenesis

• Genetic Interaction

clf-22/clf-22;ag-1/ag-1 ... leaf lamina normalized

Serrano-Cartagena J, Candela H, Robles P, Ponce MR, Pérez-Pérez JM, Piqueras P, Micol JL - Genetic analysis of incurvata mutants reveals three independent genetic operations at work in Arabidopsis leaf morphogenesis

• Genetic Interaction

leaf phenotype and flowering time of ... icu2/icu2;er/er plants, were intermediate between those of wild-type and ... icu2/icu2;ER/ER individuals

Serrano-Cartagena J, Candela H, Robles P, Ponce MR, Pérez-Pérez JM, Piqueras P, Micol JL - Genetic analysis of incurvata mutants reveals three independent genetic operations at work in Arabidopsis leaf morphogenesis

• Genetic Interaction

clf-18/clf-18;ag-1/ag-1 ... leaves showed a marginal configuration slightly different from that of the wild type, with more prominent teeth

Serrano-Cartagena J, Candela H, Robles P, Ponce MR, Pérez-Pérez JM, Piqueras P, Micol JL - Genetic analysis of incurvata mutants reveals three independent genetic operations at work in Arabidopsis leaf morphogenesis

• Genetic Interaction

icu2/icu2;icu4-1/ icu4-1 ... interpreted as a result of additivity

Serrano-Cartagena J, Candela H, Robles P, Ponce MR, Pérez-Pérez JM, Piqueras P, Micol JL - Genetic analysis of incurvata mutants reveals three independent genetic operations at work in Arabidopsis leaf morphogenesis

• Genetic Interaction

hst-5/hst-5;icu4-1/icu4-1 ... cotyledons ... were strongly curled up and often showed a darker color ... synergistic

Serrano-Cartagena J, Candela H, Robles P, Ponce MR, Pérez-Pérez JM, Piqueras P, Micol JL - Genetic analysis of incurvata mutants reveals three independent genetic operations at work in Arabidopsis leaf morphogenesis

• Genetic Interaction

clf-18/ clf-18;icu5/icu5 ... interpreted as a result of additivity

Serrano-Cartagena J, Candela H, Robles P, Ponce MR, Pérez-Pérez JM, Piqueras P, Micol JL - Genetic analysis of incurvata mutants reveals three independent genetic operations at work in Arabidopsis leaf morphogenesis

• Genetic Interaction

leaf phenotype and flowering time of clf/clf;er/er,as ... were intermediate between those of wild-type and clf/clf;ER/ ER

Serrano-Cartagena J, Candela H, Robles P, Ponce MR, Pérez-Pérez JM, Piqueras P, Micol JL - Genetic analysis of incurvata mutants reveals three independent genetic operations at work in Arabidopsis leaf morphogenesis

• Genetic Interaction

Other clf icu2 double mutants involving different clf alleles were also obtained, which showed similar synergistic phenotypes

Serrano-Cartagena J, Candela H, Robles P, Ponce MR, Pérez-Pérez JM, Piqueras P, Micol JL - Genetic analysis of incurvata mutants reveals three independent genetic operations at work in Arabidopsis leaf morphogenesis

• Genetic Interaction

se quantitatively and qualitatively enhanced the lobing of ... as2 leaves

Ori N, Eshed Y, Chuck G, Bowman JL, Hake S - Mechanisms that control knox gene expression in the Arabidopsis shoot

• Genetic Interaction

se quantitatively and qualitatively enhanced the lobing of as1 ... leaves

Ori N, Eshed Y, Chuck G, Bowman JL, Hake S - Mechanisms that control knox gene expression in the Arabidopsis shoot

• Genetic Interaction

as1 can rescue the stm phenotype in embryonic ... meristems

Byrne ME, Barley R, Curtis M, Arroyo JM, Dunham M, Hudson A, Martienssen RA - Asymmetric leaves1 mediates leaf patterning and stem cell function in Arabidopsis

• Genetic Interaction

Genetic interaction between as1 and stm

Byrne ME, Barley R, Curtis M, Arroyo JM, Dunham M, Hudson A, Martienssen RA - Asymmetric leaves1 mediates leaf patterning and stem cell function in Arabidopsis

• Genetic Interaction

as1 can rescue the stm phenotype in ... vegetative meristems

Byrne ME, Barley R, Curtis M, Arroyo JM, Dunham M, Hudson A, Martienssen RA - Asymmetric leaves1 mediates leaf patterning and stem cell function in Arabidopsis

• Genetic Interaction

phenotype of stm-1 was completely suppressed by loss of AS1

Byrne ME, Barley R, Curtis M, Arroyo JM, Dunham M, Hudson A, Martienssen RA - Asymmetric leaves1 mediates leaf patterning and stem cell function in Arabidopsis

• Genetic Interaction

stm-1 ... Epistasis of as1

Byrne ME, Barley R, Curtis M, Arroyo JM, Dunham M, Hudson A, Martienssen RA - Asymmetric leaves1 mediates leaf patterning and stem cell function in Arabidopsis

• Genetic Interaction

Genetic enhancers of kanadi1 ... kanadi2 (kan2, 3 new alleles)

Eshed Y, Baum SF, Perea JV, Bowman JL - Establishment of polarity in lateral organs of plants

• Genetic Interaction

The two kanadi mutants display a strong synergistic interaction: while kan2 has no visible aberrant phenotype on its own, it has a dramatic effect in kan1 background, even when heterozygous

Eshed Y, Baum SF, Perea JV, Bowman JL - Establishment of polarity in lateral organs of plants

• Genetic Interaction

we addressed the interaction between agb1 and er in the control of leaf shape by analyzing the agb1 er double mutant. With one exception, the double mutant has a shorter petiole, a shorter lamina, and a wider lamina than does either single mutant. The exception is that leaf width in agb1 and the double mutant do not show a statistically significant difference

Lease KA, Wen J, Li J, Doke JT, Liscum E, Walker JC - A mutant Arabidopsis heterotrimeric G-protein beta subunit affects leaf, flower, and fruit development

• Genetic Interaction

double ... heterozygotes display a synergistic phenotype ... UCU1/ucu1;SHY2/shy2-3

Pérez-Pérez JM, Ponce MR, Micol JL - The UCU1 Arabidopsis gene encodes a SHAGGY/GSK3-like kinase required for cell expansion along the proximodistal axis

• Genetic Interaction

double mutant ... ucu1-1 ... dim1-1 ... merely additive

Pérez-Pérez JM, Ponce MR, Micol JL - The UCU1 Arabidopsis gene encodes a SHAGGY/GSK3-like kinase required for cell expansion along the proximodistal axis

• Genetic Interaction

both UCU1/ucu1-3;AXR2/axr2-1 ... and UCU1/ucu1-1;AXR2/axr2-1 ... double heterozygotes display a synergistic phenotype

Pérez-Pérez JM, Ponce MR, Micol JL - The UCU1 Arabidopsis gene encodes a SHAGGY/GSK3-like kinase required for cell expansion along the proximodistal axis

• Genetic Interaction

double mutant ... ucu1-1 ... det2-1 ... merely additive

Pérez-Pérez JM, Ponce MR, Micol JL - The UCU1 Arabidopsis gene encodes a SHAGGY/GSK3-like kinase required for cell expansion along the proximodistal axis

• Genetic Interaction

ucu1 bri1 double mutant ... both the rosette and the inflorescence are more similar to those of bri1 than those of ucu1 single mutants, which suggests an epistatic effect of BRI1 over UCU1

Pérez-Pérez JM, Ponce MR, Micol JL - The UCU1 Arabidopsis gene encodes a SHAGGY/GSK3-like kinase required for cell expansion along the proximodistal axis

• Genetic Interaction

genetic interaction between AN and ZWI was shown by the finding that double-heterozygous plants of certain zwi and an allele combinations exhibit more branches than the corresponding wild types. In F1 plants from a cross between zwi-w2 and an-EM6, up to four branch points were observed. This effect was allele specific because combinations of these two alleles with other an or zwi alleles did not show extra branch formation

Folkers U, Kirik V, Schöbinger U, Falk S, Krishnakumar S, Pollock MA, Oppenheimer DG, Day I, Reddy AS, Jürgens G, Hülskamp M - The cell morphogenesis gene ANGUSTIFOLIA encodes a CtBP/BARS-like protein and is involved in the control of the microtubule cytoskeleton

• Genetic Interaction

In the flp mutant, SDD1 overexpression led to the same effects as in the wild type and sdd1-1. The transgenic lines flp SDD1#15 and flp SDD1#21 showed twofold to threefold reductions in stomatal density. Nineteen percent and 11% of the stomata were arrested at the M/GMC stage in lines flp SDD1#15 and flp SDD1#21, respectively (Figures 8C, 9E, and 9F). The stomatal index shifted from 24.3% in the flp mutant to 10.2% in line flp SDD1#15 and 13.9% in line flp SDD1#21. Thus, as shown for wild-type cv C24 and sdd1-1, the ratio of GCs to pavement cells was altered. In addition, in lines flp SDD1#15 and flp SDD1#21, the fraction of stomata arranged in clusters was unchanged (Figure 10A) . Accordingly, the effects of the loss of FLP function and increased SDD1 activity were additive

Von Groll U, Berger D, Altmann T - The subtilisin-like serine protease SDD1 mediates cell-to-cell signaling during Arabidopsis stomatal development

• Genetic Interaction

In sharp contrast to the effects of SDD1 overexpression in the wild type, in sdd1-1, or in flp, no differences in stomatal density or in average cluster size were observed between the tmm mutant and the transgenic lines tmm SDD1#1 and tmm SDD1#10 (Figures 8D and 10B). Furthermore, no arrested stomata occurred in these lines (Figures 9G and 9H). Thus, the tmm mutation acted completely epistatically to SDD1 overexpression

Von Groll U, Berger D, Altmann T - The subtilisin-like serine protease SDD1 mediates cell-to-cell signaling during Arabidopsis stomatal development

• Genetic Interaction

The hyp6 rhl2 double mutant is indistinguishable from either single mutant parent (Figure 1G), suggesting that HYP6 and RHL2 probably function in the same pathway or process

Sugimoto-Shirasu K, Stacey NJ, Corsar J, Roberts K, McCann MC - DNA topoisomerase VI is essential for endoreduplication in Arabidopsis

• Genetic Interaction

phenotype of the ga1 phyB double mutant was additive in leaf petioles

Tsukaya H, Kozuka T, Kim GT - Genetic control of petiole length in Arabidopsis thaliana

• Genetic Interaction

gai phyB double mutant was additive in leaf petioles

Tsukaya H, Kozuka T, Kim GT - Genetic control of petiole length in Arabidopsis thaliana

• Genetic Interaction

gai phyB double mutant was additive in leaf ... blades

Tsukaya H, Kozuka T, Kim GT - Genetic control of petiole length in Arabidopsis thaliana

• Genetic Interaction

gai phyB ... leaf blades of the double mutant revealed an additive phenotype with respect to the parental phenotypes under strong-light conditions

Tsukaya H, Kozuka T, Kim GT - Genetic control of petiole length in Arabidopsis thaliana

• Genetic Interaction

in petiole length ... The parental phenotypes were also additive in acl2 phyB

Tsukaya H, Kozuka T, Kim GT - Genetic control of petiole length in Arabidopsis thaliana

• Genetic Interaction

The rot3 and the acl2 mutations, which caused similar defects in petiole length, were also found to act independently of each other in leaf formation ... additive

Tsukaya H, Kozuka T, Kim GT - Genetic control of petiole length in Arabidopsis thaliana

• Genetic Interaction

in petiole length ... rot3 and phyB ... parental phenotypes were ... additive

Tsukaya H, Kozuka T, Kim GT - Genetic control of petiole length in Arabidopsis thaliana

• Genetic Interaction

stm-1/+ crossed with fil-8 yab3-2 ... loss of SAM activity in the stm-1 mutant was suppressed partially by mutations in YAB genes

Kumaran MK, Bowman JL, Sundaresan V - YABBY polarity genes mediate the repression of KNOX homeobox genes in Arabidopsis

• Genetic Interaction

In fil-8 yab3-2 stm-1 triple-mutant plants, the stm-1 phenotype was suppressed to an even greater extent

Kumaran MK, Bowman JL, Sundaresan V - YABBY polarity genes mediate the repression of KNOX homeobox genes in Arabidopsis

• Genetic Interaction

bop1-1 as2-2 ... enhancement of each mutant phenotype

Ha CM, Kim GT, Kim BC, Jun JH, Soh MS, Ueno Y, Machida Y, Tsukaya H, Nam HG - The BLADE-ON-PETIOLE 1 gene controls leaf pattern formation through the modulation of meristematic activity in Arabidopsis

• Genetic Interaction

bop1-1 as1-1 ... enhancement of each mutant phenotype

Ha CM, Kim GT, Kim BC, Jun JH, Soh MS, Ueno Y, Machida Y, Tsukaya H, Nam HG - The BLADE-ON-PETIOLE 1 gene controls leaf pattern formation through the modulation of meristematic activity in Arabidopsis

• Genetic Interaction

bop1-1 bp-1 double mutant ... phenotypes ... appear additive

Ha CM, Kim GT, Kim BC, Jun JH, Soh MS, Ueno Y, Machida Y, Tsukaya H, Nam HG - The BLADE-ON-PETIOLE 1 gene controls leaf pattern formation through the modulation of meristematic activity in Arabidopsis

• Genetic Interaction

bop1- 1 stm-1 ... appear more severe than those expected from a simple addition of the two mutant phenotypes

Ha CM, Kim GT, Kim BC, Jun JH, Soh MS, Ueno Y, Machida Y, Tsukaya H, Nam HG - The BLADE-ON-PETIOLE 1 gene controls leaf pattern formation through the modulation of meristematic activity in Arabidopsis

• Genetic Interaction

drl1-2 is epistatic to an

Nelissen H, Clarke JH, De Block M, De Block S, Vanderhaeghen R, Zielinski RE, Dyer T, Lust S, Inzé D, Van Lijsebettens M - DRL1, a homolog of the yeast TOT4/KTI12 protein, has a function in meristem activity and organ growth in plants

• Genetic Interaction

interaction between hst-1 and the adaxializing mutation kan-11

Bollman KM, Aukerman MJ, Park MY, Hunter C, Berardini TZ, Poethig RS - HASTY, the Arabidopsis ortholog of exportin 5/MSN5, regulates phase change and morphogenesis

• Genetic Interaction

HST interacts with SQUINT ... Double mutant seedlings had a much more severe phenotype than either single mutant

Bollman KM, Aukerman MJ, Park MY, Hunter C, Berardini TZ, Poethig RS - HASTY, the Arabidopsis ortholog of exportin 5/MSN5, regulates phase change and morphogenesis

• Genetic Interaction

hst-1; kan-11 ... synergistic effect of these mutations on abaxial trichome production

Bollman KM, Aukerman MJ, Park MY, Hunter C, Berardini TZ, Poethig RS - HASTY, the Arabidopsis ortholog of exportin 5/MSN5, regulates phase change and morphogenesis

• Genetic Interaction

We conclude that SQN and HST either operate cooperatively in the same regulatory pathway or operate in parallel pathways

Bollman KM, Aukerman MJ, Park MY, Hunter C, Berardini TZ, Poethig RS - HASTY, the Arabidopsis ortholog of exportin 5/MSN5, regulates phase change and morphogenesis

• Genetic Interaction

Constitutive expression of wild-type TCP2 or TCP4 partially rescued the leaf defects of jaw-D mutants

Palatnik JF, Allen E, Wu X, Schommer C, Schwab R, Carrington JC, Weigel D - Control of leaf morphogenesis by microRNAs

• Genetic Interaction

Constitutive expression of mutated MYB33 in jaw-D mutants caused an additive phenotype (not shown), consistent with the observation that MYB33 RNA was not reduced in jaw-D mutants, and further supporting the suggestion that MYB33 is primarily targeted by an miRNA other than miR-JAW, probably miR159

Palatnik JF, Allen E, Wu X, Schommer C, Schwab R, Carrington JC, Weigel D - Control of leaf morphogenesis by microRNAs

• Genetic Interaction

Constitutive expression of wild-type TCP2 ... partially rescued the leaf defects of jaw-D mutants

Palatnik JF, Allen E, Wu X, Schommer C, Schwab R, Carrington JC, Weigel D - Control of leaf morphogenesis by microRNAs

• Genetic Interaction

overexpression of ARGOS apparently restored a part of the axr1-3 leaf develop- ment ... suggests that ARGOS functions downstream of AXR1 to mediate auxin- related cell proliferation and organ growth

Hu Y, Xie Q, Chua NH - The Arabidopsis auxin-inducible gene ARGOS controls lateral organ size

• Genetic Interaction

35S-ARGOS ... ant-1 ... loss of func- tion of ANT can block ARGOS-mediated organ growth and hence ARGOS functions upstream of ANT

Hu Y, Xie Q, Chua NH - The Arabidopsis auxin-inducible gene ARGOS controls lateral organ size

• Genetic Interaction

ucu2/ucu2;det2/det2 ... double mutants ... displayed additive phenotypes

Pérez-Pérez JM, Ponce MR, Micol JL - The ULTRACURVATA2 gene of Arabidopsis encodes an FK506-binding protein involved in auxin and brassinosteroid signaling

• Genetic Interaction

We obtained ucu1/ucu1;ucu2/ucu2 double mutants (Fig. 5, A and B; Tables II and III) whose overall phenotype was in all cases the same irrespectively of the strength of the ucu1 allele involved. Their rosette phenotype was strongly different from that of each ucu/ucu single mutant and quite similar to that of bri1/bri1 plants ... the extreme rosette phenotype of the ucu1-3/ucu1-3;ucu2/ucu2 double mutants ... is clearly synergistic

Pérez-Pérez JM, Ponce MR, Micol JL - The ULTRACURVATA2 gene of Arabidopsis encodes an FK506-binding protein involved in auxin and brassinosteroid signaling

• Genetic Interaction

ucu2/ucu2; dim1/dim1 ... double mutants ... displayed additive phenotypes

Pérez-Pérez JM, Ponce MR, Micol JL - The ULTRACURVATA2 gene of Arabidopsis encodes an FK506-binding protein involved in auxin and brassinosteroid signaling

• Genetic Interaction

enhanced phenotype suggests that both ANT and JAG may function in parallel pathways that contribute to floral organ size and shape

Ohno CK, Reddy GV, Heisler MG, Meyerowitz EM - The Arabidopsis JAGGED gene encodes a zinc finger protein that promotes leaf tissue development

• Genetic Interaction

Double mutants between jag-3 and fil-1, a strong fil allele, have an additive floral phenotype

Ohno CK, Reddy GV, Heisler MG, Meyerowitz EM - The Arabidopsis JAGGED gene encodes a zinc finger protein that promotes leaf tissue development

• Genetic Interaction

Double mutant flowers harboring the null sup-5 allele and jag-3 displayed a completely additive phenotype characterized by jag-3 petal and sepal morphology, and increased stamen number and unfused carpel tissues similar to that observed in the sup-5 single mutant phenotype

Ohno CK, Reddy GV, Heisler MG, Meyerowitz EM - The Arabidopsis JAGGED gene encodes a zinc finger protein that promotes leaf tissue development

• Genetic Interaction

clv3 jag double mutants also show an additive phenotype (data not shown) suggesting that JAG does not interact with other meristem genes of the CLAVATA signaling pathway involved in maintenance of cell proliferation in the shoot and floral meristem

Ohno CK, Reddy GV, Heisler MG, Meyerowitz EM - The Arabidopsis JAGGED gene encodes a zinc finger protein that promotes leaf tissue development

• Genetic Interaction

ahk2-1 exhibited an additive effect when combined with ahk3-1

Nishimura C, Ohashi Y, Sato S, Kato T, Tabata S, Ueguchi C - Histidine kinase homologs that act as cytokinin receptors possess overlapping functions in the regulation of shoot and root growth in Arabidopsis

• Genetic Interaction

ag-1 was essentially epistatic to hua1-1 hua2-1 hen3-1 in that only perianth organs were present in hua1-1 hua2-1 hen3-1 ag-1 flowers

Wang W, Chen X - HUA ENHANCER3 reveals a role for a cyclin-dependent protein kinase in the specification of floral organ identity in Arabidopsis

• Genetic Interaction

hua1-1 hua2-1 hen3-1 clv1-4 flowers showed dramatic enlargement of the floral meristem, such that a massive group of apparently undifferentiated cells accumulated in the center of the flower (Fig. 1L). This dramatic phenotype was not observed in either hua1-1 hua2-1 hen3-1 or clv1-4 (Fig. 1K) flowers

Wang W, Chen X - HUA ENHANCER3 reveals a role for a cyclin-dependent protein kinase in the specification of floral organ identity in Arabidopsis

• Genetic Interaction

In addition to partial suppression of the hypocotyl phenotype, the hss1 mutations also suppressed the long cotyledon and pale green leaf phenotypes of hls1-1

Li H, Johnson P, Stepanova A, Alonso JM, Ecker JR - Convergence of signaling pathways in the control of differential cell growth in Arabidopsis

• Genetic Interaction

arf1 arf2-3 double mutant displayed more severe adult phenotypes than the arf2 mutant alone, and these plants were completely sterile (data not shown

Li H, Johnson P, Stepanova A, Alonso JM, Ecker JR - Convergence of signaling pathways in the control of differential cell growth in Arabidopsis

• Genetic Interaction

In addition to partial suppression of the hypocotyl phenotype, the hss1 mutations also suppressed the long cotyledon and pale green leaf phenotypes of hls1-1

Li H, Johnson P, Stepanova A, Alonso JM, Ecker JR - Convergence of signaling pathways in the control of differential cell growth in Arabidopsis

• Genetic Interaction

If TTL functions as a negative regulator in BR-mediated cell growth, its overexpression could suppress the BRI1-overexpressing phenotype. Indeed, the resulting F2 transgenic plants homozygous for both transgenes displayed wider and shorter rosette leaves than the BRI1-overexpressing transgenic plants

Nam KH, Li J - The Arabidopsis transthyretin-like protein is a potential substrate of BRASSINOSTEROID-INSENSITIVE 1

• Genetic Interaction

grf1–2 grf3 gif1 ... Its leaf area was reduced to one-half and one-third, respectively, of that of gif1 and the grf triple mutant, clearly showing an additive effect of both parental mutations

Kim JH, Kende H - A transcriptional coactivator, AtGIF1, is involved in regulating leaf growth and morphology in Arabidopsis

• Genetic Interaction

rdr6-11 hst-1 were morphologically indis- tinguishable from hst-1

Peragine A, Yoshikawa M, Wu G, Albrecht HL, Poethig RS - SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis

• Genetic Interaction

rdr6-11 sqn-1 plants had an additive pheno- type

Peragine A, Yoshikawa M, Wu G, Albrecht HL, Poethig RS - SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis

• Genetic Interaction

sgs3-11 sqn-1 ... had an additive pheno- type

Peragine A, Yoshikawa M, Wu G, Albrecht HL, Poethig RS - SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis

• Genetic Interaction

sgs3- 11 hst-1 ... were morphologically indis- tinguishable from hst-1

Peragine A, Yoshikawa M, Wu G, Albrecht HL, Poethig RS - SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis

• Genetic Interaction

hst-1 is epi- static to zip-1

Peragine A, Yoshikawa M, Wu G, Albrecht HL, Poethig RS - SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis

• Genetic Interaction

zip-1 interacts additively with sqn-1

Peragine A, Yoshikawa M, Wu G, Albrecht HL, Poethig RS - SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis

• Genetic Interaction

Phenotypic rescue of the eif3h-1 mutant was accomplished with a transgene harboring a fusion of the eIF3h promoter and coding region (Figures 2D and 2E), thus confirming that the mutant phenotypes observed were a result of the disruption of the eIF3h gene

Kim TH, Kim BH, Yahalom A, Chamovitz DA, von Arnim AG - Translational regulation via 5' mRNA leader sequences revealed by mutational analysis of the Arabidopsis translation initiation factor subunit eIF3h

• Genetic Interaction

floral phenotype of these triple mutant flowers by scoring the number of floral organs in each whorl and by examining the floral organ patterning in young floral buds using scanning electron microscopy (Table 1, Figures 6F and 6G). Similar to both bop1 bop2 and pan parents, triple mutant flowers had an average of five organs in the first whorl. Similar to the bop1 bop2 parent, a small bract or filament subtended many flowers, the abaxial organs in the sepal whorl often developed into petaloid wings, and there were on average four organs in the petal whorl. Similar to the pan-3 parent (as monitored after backcrossing to the Columbia background), bop1 bop2 pan-3 flowers had an average of four to five stamens and the occasional flower with unfused carpels. The overall phenotype of the triple mutant could best be described as a fusion between the phenotypes conferred by bop1 bop2 and pan individually, because we did not observe an additive or synergistic increase in patterning defects or in the number of perianth organs. Together, these data support the hypothesis that BOP and PAN function in the same genetic pathway and have a joint role in abaxial patterning of the floral meristem

Hepworth SR, Zhang Y, McKim S, Li X, Haughn GW - BLADE-ON-PETIOLE-dependent signaling controls leaf and floral patterning in Arabidopsis

• Genetic Interaction

elo3 elo2 ... had a narrow leaf phenotype similar to that of the respective parents ... epistasis

Nelissen H, Fleury D, Bruno L, Robles P, De Veylder L, Traas J, Micol JL, Van Montagu M, Inzé D, Van Lijsebettens M - The elongata mutants identify a functional Elongator complex in plants with a role in cell proliferation during organ growth

• Genetic Interaction

elo2 drl1-2 ... had a narrow leaf phenotype similar to that of the respective parents ... epistasis

Nelissen H, Fleury D, Bruno L, Robles P, De Veylder L, Traas J, Micol JL, Van Montagu M, Inzé D, Van Lijsebettens M - The elongata mutants identify a functional Elongator complex in plants with a role in cell proliferation during organ growth

• Genetic Interaction

elo3 elo1 ... had a narrow leaf phenotype similar to that of the respective parents ... epistasis

Nelissen H, Fleury D, Bruno L, Robles P, De Veylder L, Traas J, Micol JL, Van Montagu M, Inzé D, Van Lijsebettens M - The elongata mutants identify a functional Elongator complex in plants with a role in cell proliferation during organ growth

• Genetic Interaction

elo4 elo1 ... had a narrow leaf phenotype similar to that of the respective parents ... epistasis

Nelissen H, Fleury D, Bruno L, Robles P, De Veylder L, Traas J, Micol JL, Van Montagu M, Inzé D, Van Lijsebettens M - The elongata mutants identify a functional Elongator complex in plants with a role in cell proliferation during organ growth

• Genetic Interaction

elo2 elo1 ... had a narrow leaf phenotype similar to that of the respective parents ... epistasis

Nelissen H, Fleury D, Bruno L, Robles P, De Veylder L, Traas J, Micol JL, Van Montagu M, Inzé D, Van Lijsebettens M - The elongata mutants identify a functional Elongator complex in plants with a role in cell proliferation during organ growth

• Genetic Interaction

swp1 drl1-2 DMs ... phenotype similar to that of the swp1 mutants ... indicating that SWP1 is epistatic to DRL1

Nelissen H, Fleury D, Bruno L, Robles P, De Veylder L, Traas J, Micol JL, Van Montagu M, Inzé D, Van Lijsebettens M - The elongata mutants identify a functional Elongator complex in plants with a role in cell proliferation during organ growth

• Genetic Interaction

We screened an array of different levels of TFT in an fd-1 mutant (see Methods) and introduced the Pro35S:FT line into an fd-1 background. In all cases, loss of FD fully suppressed leaf curling and leaf-size reduction

Teper-Bamnolker P, Samach A - The flowering integrator FT regulates SEPALLATA3 and FRUITFULL accumulation in Arabidopsis leaves

• Genetic Interaction

We asked whether a mutation in SEP3 would suppress leaf curling in Pro35S:FT/TFT plants. In fact, curling of Pro35S:FT/TFT leaves was completely suppressed by replacing even one wild-type allele with the null sep3-2 allele (Col-0; Pelaz et al., 2001). Leaves of Pro35S:FT/+; sep3-2/+ and Pro35S:TFT#7/+; sep3-2/+ plants were completely uncurled and larger under conditions that promote curling

Teper-Bamnolker P, Samach A - The flowering integrator FT regulates SEPALLATA3 and FRUITFULL accumulation in Arabidopsis leaves

• Genetic Interaction

Double mutants of as1 and GTE6 T-DNA insertion mutant have curly leaves and are morphologically more similar to as1 than GTE6 mutants, suggesting that AS1 is epistatic to GTE6 ... When GTE6 was overexpressed in as1, no change in leaf shape was observed in any of the overexpressing plants, further suggesting that GTE6 regulates leaf development through AS1 ... Wild-type plants overexpressing AS1 have a phenotype similar to 35S::GTE6 plants; i.e., elliptical leaves 3 and 4, implicating both genes in control of mature leaf shape (Fig. 5F,G). These results provide genetic evidence that AS1 acts downstream of GTE6

Chua YL, Channelière S, Mott E, Gray JC - The bromodomain protein GTE6 controls leaf development in Arabidopsis by histone acetylation at ASYMMETRIC LEAVES1

• Genetic Interaction

mutations in ... ARF19 did not affect senescence of rosette leaves or floral organs on their own, they enhanced the effects of the arf2-8 mutation

Ellis CM, Nagpal P, Young JC, Hagen G, Guilfoyle TJ, Reed JW - AUXIN RESPONSE FACTOR1 and AUXIN RESPONSE FACTOR2 regulate senescence and floral organ abscission in Arabidopsis thaliana

• Genetic Interaction

mutations in NPH4/ARF7 ... did not affect senescence of rosette leaves or floral organs on their own, they enhanced the effects of the arf2-8 mutation

Ellis CM, Nagpal P, Young JC, Hagen G, Guilfoyle TJ, Reed JW - AUXIN RESPONSE FACTOR1 and AUXIN RESPONSE FACTOR2 regulate senescence and floral organ abscission in Arabidopsis thaliana

• Genetic Interaction

Both ein2 and arf2 single mutant leaves had reduced dark-induced chlorophyll loss. After incubation in the dark for 8 days, Columbia leaves retained only 18% of their chlorophyll, while arf2-8 and ein2-1 leaves retained 45% and 49%, respectively (Fig. 7A). arf2-8 ein2-1 leaves retained 76% of their chlorophyll, indicating that the mutations act additively and that delayed senescence in arf2 plants cannot be attributed solely to alterations in ethylene signaling

Ellis CM, Nagpal P, Young JC, Hagen G, Guilfoyle TJ, Reed JW - AUXIN RESPONSE FACTOR1 and AUXIN RESPONSE FACTOR2 regulate senescence and floral organ abscission in Arabidopsis thaliana

• Genetic Interaction

bp ... mutant phenotypes are suppressed by se mutant alleles

Grigg SP, Canales C, Hay A, Tsiantis M - SERRATE coordinates shoot meristem function and leaf axial patterning in Arabidopsis

• Genetic Interaction

the effects of STM mis-expression in the leaf are enhanced in se mutants

Grigg SP, Canales C, Hay A, Tsiantis M - SERRATE coordinates shoot meristem function and leaf axial patterning in Arabidopsis

• Genetic Interaction

hyp7 kak2, hyp7 rfi, and hyp7 try double mutants have small, under-branched trichomes similar to those found in hyp7, suggesting that hyp7 is epistatic to kak2, rfi, and try for the trichome growth and branching phenotypes

Sugimoto-Shirasu K, Roberts GR, Stacey NJ, McCann MC, Maxwell A, Roberts K - RHL1 is an essential component of the plant DNA topoisomerase VI complex and is required for ploidy-dependent cell growth

• Genetic Interaction

rhl1-2 rhl3-1 double mutants show a dwarf phenotype nearly identical to that of their respective parents, suggesting that, genetically, RHL1 functions in the same pathway or complex as topo VI

Sugimoto-Shirasu K, Roberts GR, Stacey NJ, McCann MC, Maxwell A, Roberts K - RHL1 is an essential component of the plant DNA topoisomerase VI complex and is required for ploidy-dependent cell growth

• Genetic Interaction

hyp7 kak2, hyp7 rfi, and hyp7 try double mutants have small, under-branched trichomes similar to those found in hyp7, suggesting that hyp7 is epistatic to kak2, rfi, and try for the trichome growth and branching phenotypes

Sugimoto-Shirasu K, Roberts GR, Stacey NJ, McCann MC, Maxwell A, Roberts K - RHL1 is an essential component of the plant DNA topoisomerase VI complex and is required for ploidy-dependent cell growth

• Genetic Interaction

hyp7 kak2, hyp7 rfi, and hyp7 try double mutants have small, under-branched trichomes similar to those found in hyp7, suggesting that hyp7 is epistatic to kak2, rfi, and try for the trichome growth and branching phenotypes

Sugimoto-Shirasu K, Roberts GR, Stacey NJ, McCann MC, Maxwell A, Roberts K - RHL1 is an essential component of the plant DNA topoisomerase VI complex and is required for ploidy-dependent cell growth

• Genetic Interaction

rhl1-2 rhl2-1 ... double mutants show a dwarf phenotype nearly identical to that of their respective parents, suggesting that, genetically, RHL1 functions in the same pathway or complex as topo VI

Sugimoto-Shirasu K, Roberts GR, Stacey NJ, McCann MC, Maxwell A, Roberts K - RHL1 is an essential component of the plant DNA topoisomerase VI complex and is required for ploidy-dependent cell growth

• Genetic Interaction

dexamethasone (Dex)-inducible system ... Arabidopsis transgenic plants that can express geminivirus RepA protein (RepAwt) in an inducible manner ... To evaluate whether RepAwt could release endogenous E2F in planta, we determined E2F DNA-binding activity in extracts of control and transgenic plants ... with ... Dex treatment ... electrophoretic mobility shift assay (EMSA) using an oligonucleotide containing a consensus E2F-binding site ... produced a ... increase of E2F-binding activity in whole-cell extracts

Desvoyes B, Ramirez-Parra E, Xie Q, Chua NH, Gutierrez C - Cell type-specific role of the retinoblastoma/E2F pathway during Arabidopsis leaf development

• Genetic Interaction

Although there was some variability in the degree of rescue, both PER:BAM1 and PER:CLV1 expression in bam1 bam2 plants were capable of completely rescuing the Bam− phenotypes (Figure 6c). This indicates that the ER regulatory elements drive sufficiently broad expression and that CLV1 can replace BAM function outside of the meristem

DeYoung BJ, Bickle KL, Schrage KJ, Muskett P, Patel K, Clark SE - The CLAVATA1-related BAM1, BAM2 and BAM3 receptor kinase-like proteins are required for meristem function in Arabidopsis

• Genetic Interaction

TRN2 ... epistatic to AS1 with respect to leaf asymmetry

Cnops G, Neyt P, Raes J, Petrarulo M, Nelissen H, Malenica N, Luschnig C, Tietz O, Ditengou F, Palme K, Azmi A, Prinsen E, Van Lijsebettens M - The TORNADO1 and TORNADO2 genes function in several patterning processes during early leaf development in Arabidopsis thaliana

• Genetic Interaction

lamina area in as1-1 trn2-1 ... intermediate compared with those of their parents

Cnops G, Neyt P, Raes J, Petrarulo M, Nelissen H, Malenica N, Luschnig C, Tietz O, Ditengou F, Palme K, Azmi A, Prinsen E, Van Lijsebettens M - The TORNADO1 and TORNADO2 genes function in several patterning processes during early leaf development in Arabidopsis thaliana

• Genetic Interaction

The reduction in venation complexity produced in as1-1 and trn2-1 single mutants was even more pronounced in the double mutant

Cnops G, Neyt P, Raes J, Petrarulo M, Nelissen H, Malenica N, Luschnig C, Tietz O, Ditengou F, Palme K, Azmi A, Prinsen E, Van Lijsebettens M - The TORNADO1 and TORNADO2 genes function in several patterning processes during early leaf development in Arabidopsis thaliana

• Genetic Interaction

TRN1 ... epistatic to AS1 with respect to leaf asymmetry

Cnops G, Neyt P, Raes J, Petrarulo M, Nelissen H, Malenica N, Luschnig C, Tietz O, Ditengou F, Palme K, Azmi A, Prinsen E, Van Lijsebettens M - The TORNADO1 and TORNADO2 genes function in several patterning processes during early leaf development in Arabidopsis thaliana

• Genetic Interaction

No obvious phenotype different from those of trn1-2 or trn2-4

Cnops G, Neyt P, Raes J, Petrarulo M, Nelissen H, Malenica N, Luschnig C, Tietz O, Ditengou F, Palme K, Azmi A, Prinsen E, Van Lijsebettens M - The TORNADO1 and TORNADO2 genes function in several patterning processes during early leaf development in Arabidopsis thaliana

• Genetic Interaction

total leaf length ... in as1-1 trn2-1 ... intermediate compared with those of their parents

Cnops G, Neyt P, Raes J, Petrarulo M, Nelissen H, Malenica N, Luschnig C, Tietz O, Ditengou F, Palme K, Azmi A, Prinsen E, Van Lijsebettens M - The TORNADO1 and TORNADO2 genes function in several patterning processes during early leaf development in Arabidopsis thaliana

• Genetic Interaction

as1-1 ... trn2-1 ... brp:lamina area ratio was more reduced in the double mutant than in both single mutants

Cnops G, Neyt P, Raes J, Petrarulo M, Nelissen H, Malenica N, Luschnig C, Tietz O, Ditengou F, Palme K, Azmi A, Prinsen E, Van Lijsebettens M - The TORNADO1 and TORNADO2 genes function in several patterning processes during early leaf development in Arabidopsis thaliana

• Genetic Interaction

the mutant phenotype caused by homozygosis of crc-1 is enhanced by the gain-of-function allele icu4-1

Ochando I, Jover-Gil S, Ripoll JJ, Candela H, Vera A, Ponce MR, Martínez-Laborda A, Micol JL - Mutations in the microRNA complementarity site of the INCURVATA4 gene perturb meristem function and adaxialize lateral organs in arabidopsis

• Genetic Interaction

We previously described a synergistic interaction between the icu4 and hst mutations based on the rosette phenotype of the icu4-1 hst-5 double mutants (Serrano-Cartagena et al., 2000)

Ochando I, Jover-Gil S, Ripoll JJ, Candela H, Vera A, Ponce MR, Martínez-Laborda A, Micol JL - Mutations in the microRNA complementarity site of the INCURVATA4 gene perturb meristem function and adaxialize lateral organs in arabidopsis

• Genetic Interaction

icu4-1/icu4-1;pkl-1/pkl-1 double mutants showed phenotypes that might be considered merely additive

Ochando I, Jover-Gil S, Ripoll JJ, Candela H, Vera A, Ponce MR, Martínez-Laborda A, Micol JL - Mutations in the microRNA complementarity site of the INCURVATA4 gene perturb meristem function and adaxialize lateral organs in arabidopsis

• Genetic Interaction

The icu4-1/icu4-1;kan1-2/kan1-2 ... double mutants showed phenotypes that might be considered merely additive

Ochando I, Jover-Gil S, Ripoll JJ, Candela H, Vera A, Ponce MR, Martínez-Laborda A, Micol JL - Mutations in the microRNA complementarity site of the INCURVATA4 gene perturb meristem function and adaxialize lateral organs in arabidopsis

• Genetic Interaction

The ett muta- tion has no impact on leaf development alone, but strongly suppresses the enhancement of as1 by ago7/ zip, so that triple mutants have smoother leaves with normal margins, resembling those of as1

Garcia D, Collier SA, Byrne ME, Martienssen RA - Specification of leaf polarity in Arabidopsis via the trans-acting siRNA pathway

• Genetic Interaction

a screen for second-site mutations that enhance as1 leaf-shape defects ... We identified, via allel- ism analysis and sequencing ... two alleles of sgs3 among the enhancers

Garcia D, Collier SA, Byrne ME, Martienssen RA - Specification of leaf polarity in Arabidopsis via the trans-acting siRNA pathway

• Genetic Interaction

In a screen for second-site mutations that enhance as1 leaf-shape defects, several classes of modifiers were identified (M.E.B and R.A.M., unpublished data). In one class, 18 mutants had similar or identical phenotypes. These mutants fell into at least four complementation groups, and included rdr6 [18, 19], which has been pre- viously reported to interact with as1

Garcia D, Collier SA, Byrne ME, Martienssen RA - Specification of leaf polarity in Arabidopsis via the trans-acting siRNA pathway

• Genetic Interaction

In a screen for second-site mutations that enhance as1 leaf-shape defects ... We identified, via allel- ism analysis and sequencing, one additional allele of ago7 ... among the enhancers

Garcia D, Collier SA, Byrne ME, Martienssen RA - Specification of leaf polarity in Arabidopsis via the trans-acting siRNA pathway

• Genetic Interaction

This partial loss of STM function did not alter leaf shape in as1 rdr6 stm-2 triple mutants, which appeared additive (data not shown

Garcia D, Collier SA, Byrne ME, Martienssen RA - Specification of leaf polarity in Arabidopsis via the trans-acting siRNA pathway

• Genetic Interaction

An enhancer-trap insertion (ET5446) into AGO7/ZIP (ago7-m5446, also known as ago7-jason) was also found to enhance as1

Garcia D, Collier SA, Byrne ME, Martienssen RA - Specification of leaf polarity in Arabidopsis via the trans-acting siRNA pathway

• Genetic Interaction

sca3-2 rpoT;2 double mutants was arrested early after germination, when they displayed pale-green or bleached expanded cotyledons, and only a few of them produced a few leaves, which were extremely abnormal and tiny ... Genetic interaction between the SCA3 and RpoTmp genes

Hricová A, Quesada V, Micol JL - The SCABRA3 nuclear gene encodes the plastid RpoTp RNA polymerase, which is required for chloroplast biogenesis and mesophyll cell proliferation in Arabidopsis

• Genetic Interaction

dcl1 ... appeared to suppress the as2 phenotypes

Xu L, Yang L, Pi L, Liu Q, Ling Q, Wang H, Poethig RS, Huang H - Genetic interaction between the AS1-AS2 and RDR6-SGS3-AGO7 pathways for leaf morphogenesis

• Genetic Interaction

In comparison with the ago1-27 single mutant, ago1-27 as2-101 ... had enhanced as2 ... phenotypes

Xu L, Yang L, Pi L, Liu Q, Ling Q, Wang H, Poethig RS, Huang H - Genetic interaction between the AS1-AS2 and RDR6-SGS3-AGO7 pathways for leaf morphogenesis

• Genetic Interaction

hyl1 ... appeared to suppress the as2 phenotypes

Xu L, Yang L, Pi L, Liu Q, Ling Q, Wang H, Poethig RS, Huang H - Genetic interaction between the AS1-AS2 and RDR6-SGS3-AGO7 pathways for leaf morphogenesis

• Genetic Interaction

In comparison with the ago1-27 single mutant ... ago1-27 as1-101 had enhanced ... as1 phenotypes

Xu L, Yang L, Pi L, Liu Q, Ling Q, Wang H, Poethig RS, Huang H - Genetic interaction between the AS1-AS2 and RDR6-SGS3-AGO7 pathways for leaf morphogenesis

• Genetic Interaction

Next, we introduced 35S-ARL into bri1–119 to examine the impact of overexpressed ARL on cotyledon and leaf growth. Compared with control bri1–119 seedlings, which contained an empty vector and displayed the mutant phenotype with smaller cotyledons and compact leaves, overexpression of ARL ... in part also restored the bri1–119 leaf growth

Hu Y, Poh HM, Chua NH - The Arabidopsis ARGOS-LIKE gene regulates cell expansion during organ growth

• Genetic Interaction

Next, we introduced 35S-ARL into bri1–119 to examine the impact of overexpressed ARL on cotyledon and leaf growth. Compared with control bri1–119 seedlings, which contained an empty vector and displayed the mutant phenotype with smaller cotyledons and compact leaves, overexpression of ARL apparently rescued cotyledon growth

Hu Y, Poh HM, Chua NH - The Arabidopsis ARGOS-LIKE gene regulates cell expansion during organ growth

• Genetic Interaction

the larger rosette size of agb1-2 was also suppressed (Figure 1D) but other agb1-2 phenotypes such as leaf shape (Figure 1F) were only partially suppressed, and others such as silique shape (our unpublished data) were not suppressed at all by the sgb1-1D mutation

Wang HX, Weerasinghe RR, Perdue TD, Cakmakci NG, Taylor JP, Marzluff WF, Jones AM - A Golgi-localized hexose transporter is involved in heterotrimeric G protein-mediated early development in Arabidopsis

• Genetic Interaction

To confirm that the dominant suppressor phenotypes was a consequence of overexpression at this locus, the full-length cDNA encoded by the At1g79820 locus was placed under the control of the cauliflower mosaic viral 35S promoter and transformed into the parent agb1-2 mutant. Hypocotyl and hook phenotypes of agb1-2 mutant were restored to wild type in three independent transgenic lines overexpressing the At1g79820 cDNA in agb1-2 (Figure 2, B and C, lines 1–3, and D). The d-glucose hypersensitivity of agb1-2 hypocotyls was also rescued when At1g79820 was overexpressed (Figure 2D). These results support our conclusion that enhanced expression of At1g79820 causes suppression of the agb1 phenotypes in sgb1-1D agb1-2 and based on these, we designate At1g79820 as SGB1

Wang HX, Weerasinghe RR, Perdue TD, Cakmakci NG, Taylor JP, Marzluff WF, Jones AM - A Golgi-localized hexose transporter is involved in heterotrimeric G protein-mediated early development in Arabidopsis

• Genetic Interaction

epistasis between loss-of-function alleles of agb1 and sgb1-2 suggests that AGB1 acts as a positive regulator of SGB1 in the early seedling development

Wang HX, Weerasinghe RR, Perdue TD, Cakmakci NG, Taylor JP, Marzluff WF, Jones AM - A Golgi-localized hexose transporter is involved in heterotrimeric G protein-mediated early development in Arabidopsis

• Genetic Interaction

The phenotype of the dov1/dov1;re-3/re-3 double mutants was merely additive, as expected if the DOV1 and RE genes act in an independent manner

González-Bayón R, Kinsman EA, Quesada V, Vera A, Robles P, Ponce MR, Pyke KA, Micol JL - Mutations in the RETICULATA gene dramatically alter internal architecture but have little effect on overall organ shape in Arabidopsis leaves

• Genetic Interaction

cue1-5 is epistatic to re-3 and suggests that RE and CUE1 act in the same developmental pathway affecting leaf development

González-Bayón R, Kinsman EA, Quesada V, Vera A, Robles P, Ponce MR, Pyke KA, Micol JL - Mutations in the RETICULATA gene dramatically alter internal architecture but have little effect on overall organ shape in Arabidopsis leaves

• Genetic Interaction

The cotyledons of these double mutants displayed an additive phenotype consisting of the simple vascular pattern characteristic of hve-3, combined with the vein disconnections characteristic of cvp1-3

Alonso-Peral MM, Candela H, del Pozo JC, Martínez-Laborda A, Ponce MR, Micol JL - The HVE/CAND1 gene is required for the early patterning of leaf venation in Arabidopsis

• Genetic Interaction

An additive phenotype was found in the hve-3/hve-3;cvp2-1/cvp2-1 double mutants ... simple venation pattern

Alonso-Peral MM, Candela H, del Pozo JC, Martínez-Laborda A, Ponce MR, Micol JL - The HVE/CAND1 gene is required for the early patterning of leaf venation in Arabidopsis

• Genetic Interaction

hve-3/hve-3;pin1cay/pin1cay double mutants with an additive phenotype

Alonso-Peral MM, Candela H, del Pozo JC, Martínez-Laborda A, Ponce MR, Micol JL - The HVE/CAND1 gene is required for the early patterning of leaf venation in Arabidopsis

• Genetic Interaction

additive phenotype ... of hve-1/hve-1;pin1-1/pin1-1 double mutants

Alonso-Peral MM, Candela H, del Pozo JC, Martínez-Laborda A, Ponce MR, Micol JL - The HVE/CAND1 gene is required for the early patterning of leaf venation in Arabidopsis

• Genetic Interaction

Leaf phenotypes of the as1;axr1 double mutant were enhanced with respect to either single mutant, with dee

Hay A, Barkoulas M, Tsiantis M - ASYMMETRIC LEAVES1 and auxin activities converge to repress BREVIPEDICELLUS expression and promote leaf development in Arabidopsis

• Genetic Interaction

Strong pin1 mutants with impaired auxin transport, therefore, initiate a reduced number of leaves and no flowers (Okada et al., 1991). However, pin1;as1 double mutants initiate significantly fewer leaves than do pin1 single mutants

Hay A, Barkoulas M, Tsiantis M - ASYMMETRIC LEAVES1 and auxin activities converge to repress BREVIPEDICELLUS expression and promote leaf development in Arabidopsis

• Genetic Interaction

ectopic expression of BP in the axr1 leaf is not responsible for the mild leaf phenotypes that distinguish axr1 from wild type (Lincoln et al., 1990), as bp;axr1 double mutant leaves appeared identical to axr1 single mutants

Hay A, Barkoulas M, Tsiantis M - ASYMMETRIC LEAVES1 and auxin activities converge to repress BREVIPEDICELLUS expression and promote leaf development in Arabidopsis

• Genetic Interaction

To test whether PIN1 promotes lateral organ development by regulating BP, we analysed pin1;bp double mutants, predicting that those aspects of the pin1 phenotype that are BP dependent will be suppressed. We observed that the failure of pin1 mutants to initiate both leaves and flowers is partially rescued in these double mutants

Hay A, Barkoulas M, Tsiantis M - ASYMMETRIC LEAVES1 and auxin activities converge to repress BREVIPEDICELLUS expression and promote leaf development in Arabidopsis

• Genetic Interaction

Ectopic stipules observed in cauline leaves of as1;axr1 double mutants, but not in as1 or axr1 single mutants, were not found in as1;axr1;bp triple mutants (Fig. 1W-Y, n=20 triple mutant leaves), indicating that their initiation is likely to depend on BP activity

Hay A, Barkoulas M, Tsiantis M - ASYMMETRIC LEAVES1 and auxin activities converge to repress BREVIPEDICELLUS expression and promote leaf development in Arabidopsis

• Genetic Interaction

quantification of trichome branching showed no additive or synergistic effects between ... fas1-1 fas2-1

Exner V, Taranto P, Schönrock N, Gruissem W, Hennig L - Chromatin assembly factor CAF-1 is required for cellular differentiation during plant development

• Genetic Interaction

fas1-4 fas2-4 ... were viable, similar to the previously described fas1-1 fas2-1 double mutant (Hennig et al., 2003), and no obvious synergistic effects were observed during development

Exner V, Taranto P, Schönrock N, Gruissem W, Hennig L - Chromatin assembly factor CAF-1 is required for cellular differentiation during plant development

• Genetic Interaction

quantification of trichome branching showed no additive or synergistic effects ... fas1-1 msi1-as

Exner V, Taranto P, Schönrock N, Gruissem W, Hennig L - Chromatin assembly factor CAF-1 is required for cellular differentiation during plant development

• Genetic Interaction

fas1-4 msi1-as ... were viable, similar to the previously described fas1-1 fas2-1 double mutant (Hennig et al., 2003), and no obvious synergistic effects were observed during development

Exner V, Taranto P, Schönrock N, Gruissem W, Hennig L - Chromatin assembly factor CAF-1 is required for cellular differentiation during plant development

• Genetic Interaction

fas2-4 msi1-as ... were viable, similar to the previously described fas1-1 fas2-1 double mutant (Hennig et al., 2003), and no obvious synergistic effects were observed during development

Exner V, Taranto P, Schönrock N, Gruissem W, Hennig L - Chromatin assembly factor CAF-1 is required for cellular differentiation during plant development

• Genetic Interaction

quantification of trichome branching showed no additive or synergistic effects ... fas2-1 msi1-as double mutants

Exner V, Taranto P, Schönrock N, Gruissem W, Hennig L - Chromatin assembly factor CAF-1 is required for cellular differentiation during plant development

• Genetic Interaction

In particular, quantification of trichome branching showed no additive or synergistic effects between fas1-4, fas2-4

Exner V, Taranto P, Schönrock N, Gruissem W, Hennig L - Chromatin assembly factor CAF-1 is required for cellular differentiation during plant development

• Genetic Interaction

the trichome branching phenotype of the fas2-1 gl3-1 double mutant was intermediate to the two single mutants, with only 4% single-ended trichomes and 10% three-ended trichomes ... additive ... interaction

Exner V, Taranto P, Schönrock N, Gruissem W, Hennig L - Chromatin assembly factor CAF-1 is required for cellular differentiation during plant development

• Genetic Interaction

particular, quantification of trichome branching showed no additive or synergistic effects between fas1-4 ... and msi1-as

Exner V, Taranto P, Schönrock N, Gruissem W, Hennig L - Chromatin assembly factor CAF-1 is required for cellular differentiation during plant development

• Genetic Interaction

In particular, quantification of trichome branching showed no additive or synergistic effects between ... fas2-4 and msi1-as

Exner V, Taranto P, Schönrock N, Gruissem W, Hennig L - Chromatin assembly factor CAF-1 is required for cellular differentiation during plant development

• Genetic Interaction

may ... rot3-1 is epistatic to lng1-1D for leaf-width expansion

Lee YK, Kim GT, Kim IJ, Park J, Kwak SS, Choi G, Chung WI - LONGIFOLIA1 and LONGIFOLIA2, two homologous genes, regulate longitudinal cell elongation in Arabidopsis

• Genetic Interaction

suggests ... AN is epistatic to LNG1 for the width elongation of leaf blades

Lee YK, Kim GT, Kim IJ, Park J, Kwak SS, Choi G, Chung WI - LONGIFOLIA1 and LONGIFOLIA2, two homologous genes, regulate longitudinal cell elongation in Arabidopsis

• Genetic Interaction

CUC2 is required for the serrated leaf phenotype of the mir164a-4 mutant

Nikovics K, Blein T, Peaucelle A, Ishida T, Morin H, Aida M, Laufs P - The balance between the MIR164A and CUC2 genes controls leaf margin serration in Arabidopsis

• Genetic Interaction

The phenotypes of ... mute; fama double mutants were indistinguishable from that of mute ... mute; fama ... The epistasis of MUTE over ... FAMA is consistent with MUTE acting at an earlier step of stomatal differentiation

Pillitteri LJ, Sloan DB, Bogenschutz NL, Torii KU - Termination of asymmetric cell division and differentiation of stomata

• Genetic Interaction

The phenotypes of mute; flp ... were indistinguishable from that of mute ... The epistasis of MUTE over FLP ... is consistent with MUTE acting at an earlier step of stomatal differentiation

Pillitteri LJ, Sloan DB, Bogenschutz NL, Torii KU - Termination of asymmetric cell division and differentiation of stomata

• Genetic Interaction

we found no additional phenotype in trn2-2 3010 wus-1 ... during the vegetative phase

Chiu WH, Chandler J, Cnops G, Van Lijsebettens M, Werr W - Mutations in the TORNADO2 gene affect cellular decisions in the peripheral zone of the shoot apical meristem of Arabidopsis thaliana

• Genetic Interaction

we found no additional phenotype in ... trn2-2 ... clv3-2 mutants during the vegetative phase

Chiu WH, Chandler J, Cnops G, Van Lijsebettens M, Werr W - Mutations in the TORNADO2 gene affect cellular decisions in the peripheral zone of the shoot apical meristem of Arabidopsis thaliana

• Genetic Interaction

rescue of the stm mutant phenotype by trn2-2 3010 was also observed in the weaker stm-5 background

Chiu WH, Chandler J, Cnops G, Van Lijsebettens M, Werr W - Mutations in the TORNADO2 gene affect cellular decisions in the peripheral zone of the shoot apical meristem of Arabidopsis thaliana

• Genetic Interaction

To further confirm that overexpression of At2g45400 is responsible for the enhanced bri1-5-defective phenotype, the CaMV 35S promoter was used to drive the expression of At2g45400 cDNA in the bri1-5 mutant. Of 60 transgenic plants examined, 12 lines(20%) showed obvious enhanced bri1-5-defective phenotypes

Yuan T, Fujioka S, Takatsuto S, Matsumoto S, Gou X, He K, Russell SD, Li J - BEN1, a gene encoding a dihydroflavonol 4-reductase (DFR)-like protein, regulates the levels of brassinosteroids in Arabidopsis thaliana

• Genetic Interaction

From about 120 000 activation-tagging lines generated in bri1-5, ben1-1D was identified as a bri1-5 extragenic enhancers

Yuan T, Fujioka S, Takatsuto S, Matsumoto S, Gou X, He K, Russell SD, Li J - BEN1, a gene encoding a dihydroflavonol 4-reductase (DFR)-like protein, regulates the levels of brassinosteroids in Arabidopsis thaliana

• Genetic Interaction

synergistic genetic interaction between BOP1 and BOP2

Ha CM, Jun JH, Nam HG, Fletcher JC - BLADE-ON-PETIOLE 1 and 2 control Arabidopsis lateral organ fate through regulation of LOB domain and adaxial-abaxial polarity genes

• Genetic Interaction

the er mutation is required for the appearance of the severe phenotypic defects in Ler 35S:BOP1 plants

Ha CM, Jun JH, Nam HG, Fletcher JC - BLADE-ON-PETIOLE 1 and 2 control Arabidopsis lateral organ fate through regulation of LOB domain and adaxial-abaxial polarity genes

• Genetic Interaction

The vascular patterning defects in the ... bop1 bop2 as2 leaf petioles were greatly enhanced compared with those of the parental plants

Ha CM, Jun JH, Nam HG, Fletcher JC - BLADE-ON-PETIOLE 1 and 2 control Arabidopsis lateral organ fate through regulation of LOB domain and adaxial-abaxial polarity genes

• Genetic Interaction

The vascular patterning defects in the bop1 bop2 as1 ... leaf petioles were greatly enhanced compared with those of the parental plants

Ha CM, Jun JH, Nam HG, Fletcher JC - BLADE-ON-PETIOLE 1 and 2 control Arabidopsis lateral organ fate through regulation of LOB domain and adaxial-abaxial polarity genes

• Genetic Interaction

These data reveal a synergistic interaction between the bop1 bop2 and kan1 kan2 alleles in controlling lateral organ polarity in the basal regions of the leaf

Ha CM, Jun JH, Nam HG, Fletcher JC - BLADE-ON-PETIOLE 1 and 2 control Arabidopsis lateral organ fate through regulation of LOB domain and adaxial-abaxial polarity genes

• Genetic Interaction

AG ... epistatic to ICU2

Barrero JM, González-Bayón R, del Pozo JC, Ponce MR, Micol JL - INCURVATA2 encodes the catalytic subunit of DNA Polymerase alpha and interacts with genes involved in chromatin-mediated cellular memory in Arabidopsis thaliana

• Genetic Interaction

ft-1 ... clf-2 ... double mutants displayed the leaf morphology of ... clf-2 ... and late flowering, such as that of ft-1

Barrero JM, González-Bayón R, del Pozo JC, Ponce MR, Micol JL - INCURVATA2 encodes the catalytic subunit of DNA Polymerase alpha and interacts with genes involved in chromatin-mediated cellular memory in Arabidopsis thaliana

• Genetic Interaction

ft-1 ... icu2-1 ... double mutants displayed the leaf morphology of ... icu2-1 ... and late flowering, such as that of ft-1

Barrero JM, González-Bayón R, del Pozo JC, Ponce MR, Micol JL - INCURVATA2 encodes the catalytic subunit of DNA Polymerase alpha and interacts with genes involved in chromatin-mediated cellular memory in Arabidopsis thaliana

• Genetic Interaction

FT ... epistatic to ICU2

Barrero JM, González-Bayón R, del Pozo JC, Ponce MR, Micol JL - INCURVATA2 encodes the catalytic subunit of DNA Polymerase alpha and interacts with genes involved in chromatin-mediated cellular memory in Arabidopsis thaliana

• Genetic Interaction

Double mutants of mid-1 with mutants forming trichomes with a DNA content of 64C, such as ... kaktus ... exhibit a small trichome phenotype indistinguishable from mid-1 (data not shown). This epistatic behavior of the mid-1 mutation suggests that the MID gene is essential for the progression of endoreduplication cycles

Kirik V, Schrader A, Uhrig JF, Hulskamp M - MIDGET unravels functions of the Arabidopsis topoisomerase VI complex in DNA endoreduplication, chromatin condensation, and transcriptional silencing

• Genetic Interaction

To test genetically whether MID is involved in chromatin organization, we created a double mutant of mid-1 with a mutant defective in the p150 subunit (fasciata1 [fas1]) of chromatin assembly factor1 that was shown to affect the heterochromatin formation in nonmitotic cells in Arabidopsis (Kirik et al., 2006). The double mutant displayed dramatically reduced seedlings size and died shortly after germination (Figure 5A). This synergistic phenotype suggests the involvement of the Arabidopsis topoisomerase VI in chromatin organization

Kirik V, Schrader A, Uhrig JF, Hulskamp M - MIDGET unravels functions of the Arabidopsis topoisomerase VI complex in DNA endoreduplication, chromatin condensation, and transcriptional silencing

• Genetic Interaction

Double mutants of mid-1 with mutants forming trichomes with a DNA content of 64C, such as triptychon ... exhibit a small trichome phenotype indistinguishable from mid-1 (data not shown). This epistatic behavior of the mid-1 mutation suggests that the MID gene is essential for the progression of endoreduplication cycles

Kirik V, Schrader A, Uhrig JF, Hulskamp M - MIDGET unravels functions of the Arabidopsis topoisomerase VI complex in DNA endoreduplication, chromatin condensation, and transcriptional silencing

• Genetic Interaction

Double mutants of mid-1 with mutants forming trichomes with a DNA content of 64C, such as ... rastafari, exhibit a small trichome phenotype indistinguishable from mid-1 (data not shown). This epistatic behavior of the mid-1 mutation suggests that the MID gene is essential for the progression of endoreduplication cycles

Kirik V, Schrader A, Uhrig JF, Hulskamp M - MIDGET unravels functions of the Arabidopsis topoisomerase VI complex in DNA endoreduplication, chromatin condensation, and transcriptional silencing

• Genetic Interaction

Our real-time RT-PCR analysis revealed that the expression level of several DNA damage response genes, including PARP1, PARP2, BRCA1, and RAD51, is 1.7 to 9 times higher in bin4 compared with wild-type seedlings ... we found that ... atm ... partially suppress these transcriptional activations in bin4

Breuer C, Stacey NJ, West CE, Zhao Y, Chory J, Tsukaya H, Azumi Y, Maxwell A, Roberts K, Sugimoto-Shirasu K - BIN4, a novel component of the plant DNA topoisomerase VI complex, is required for endoreduplication in Arabidopsis

• Genetic Interaction

The double mutant analyses with the overendoreduplicated, overbranched trichome mutants ... kaktus2 (kak2) ... showed that none of these mutations modify the bin4 phenotype (see Supplemental Figure 2 online). These results suggest that BIN4 functions genetically in a pathway that is either downstream or independent of these negative regulators in trichome and root hair formation

Breuer C, Stacey NJ, West CE, Zhao Y, Chory J, Tsukaya H, Azumi Y, Maxwell A, Roberts K, Sugimoto-Shirasu K - BIN4, a novel component of the plant DNA topoisomerase VI complex, is required for endoreduplication in Arabidopsis

• Genetic Interaction

The double mutant analyses with the overendoreduplicated, overbranched trichome mutants ... rastafari (rfi) ... showed that none of these mutations modify the bin4 phenotype (see Supplemental Figure 2 online). These results suggest that BIN4 functions genetically in a pathway that is either downstream or independent of these negative regulators in trichome and root hair formation

Breuer C, Stacey NJ, West CE, Zhao Y, Chory J, Tsukaya H, Azumi Y, Maxwell A, Roberts K, Sugimoto-Shirasu K - BIN4, a novel component of the plant DNA topoisomerase VI complex, is required for endoreduplication in Arabidopsis

• Genetic Interaction

Our real-time RT-PCR analysis revealed that the expression level of several DNA damage response genes, including PARP1, PARP2, BRCA1, and RAD51, is 1.7 to 9 times higher in bin4 compared with wild-type seedlings ... we found that ... atr ... partially suppress these transcriptional activations in bin4

Breuer C, Stacey NJ, West CE, Zhao Y, Chory J, Tsukaya H, Azumi Y, Maxwell A, Roberts K, Sugimoto-Shirasu K - BIN4, a novel component of the plant DNA topoisomerase VI complex, is required for endoreduplication in Arabidopsis

• Genetic Interaction

The double mutant analyses with the overendoreduplicated, overbranched trichome mutants triptychon (try) ... showed that none of these mutations modify the bin4 phenotype (see Supplemental Figure 2 online). These results suggest that BIN4 functions genetically in a pathway that is either downstream or independent of these negative regulators in trichome and root hair formation

Breuer C, Stacey NJ, West CE, Zhao Y, Chory J, Tsukaya H, Azumi Y, Maxwell A, Roberts K, Sugimoto-Shirasu K - BIN4, a novel component of the plant DNA topoisomerase VI complex, is required for endoreduplication in Arabidopsis

• Genetic Interaction

We also observed an enhancement of the phb-1d homozygous phenotype in ... phb-1d seu ant mutants ... the loss of ... SEU and ANT together, caused a further radialization and loss of laminar expansion of rosette leaves in the phb-1d homozygote background. In these plants almost all leaves were completely radialized and rod shaped

Azhakanandam S, Nole-Wilson S, Bao F, Franks RG - SEUSS and AINTEGUMENTA mediate patterning and ovule initiation during gynoecium medial domain development

• Genetic Interaction

We also observed an enhancement of the phb-1d homozygous phenotype in phb-1d seu double ... mutants ... the loss of SEU ... caused a further radialization and loss of laminar expansion of rosette leaves in the phb-1d homozygote background. In these plants almost all leaves were completely radialized and rod shaped

Azhakanandam S, Nole-Wilson S, Bao F, Franks RG - SEUSS and AINTEGUMENTA mediate patterning and ovule initiation during gynoecium medial domain development

• Genetic Interaction

we observed enhanced radialization and narrowing of rosette leaves in the phb-1d/+ seu ant mutants (Fig. 7C) approaching that exhibited by the phb-1d homozygote

Azhakanandam S, Nole-Wilson S, Bao F, Franks RG - SEUSS and AINTEGUMENTA mediate patterning and ovule initiation during gynoecium medial domain development

• Genetic Interaction

we observed enhanced radialization and narrowing of rosette leaves in the phb-1d/+ seu ant mutants (Fig. 7C) approaching that exhibited by the phb-1d homozygote

Azhakanandam S, Nole-Wilson S, Bao F, Franks RG - SEUSS and AINTEGUMENTA mediate patterning and ovule initiation during gynoecium medial domain development

• Genetic Interaction

We also identified an enhancer of da1-1 (eod1-1) ... Both a T-DNA insertion in the 3′ untranslated region (UTR) (eod1-2) and the original bb-1 mutation also enhanced the da1-1 phenotypes ... Seed and petal measurements in eod1-2da1-1 and bb-1da1-1Ler double mutants demonstrated a synergistic enhancement of seed and organ size of da1-1 by mutations in EOD1/BB (Fig. 5B–E; Supplemental Fig. 9C–E), suggesting that the two genes act in parallel pathways to control the final size of seeds and organs in Arabidopsis

Li Y, Zheng L, Corke F, Smith C, Bevan MW - Control of final seed and organ size by the DA1 gene family in Arabidopsis thaliana

• Genetic Interaction

while Pro35S:MIR156f se-1 double mutants retained the serrated leaf phenotype typical of se-1 mutants, the plasto- chron defect caused by miR156 overexpression was suppressed in these plants (see Supplemental Figure 1C online).

Wang JW, Schwab R, Czech B, Mica E, Weigel D - Dual effects of miR156-targeted SPL genes and CYP78A5/KLUH on plastochron length and organ size in Arabidopsis thaliana

• Genetic Interaction

In case of ARF5 overexpression, out of 19 plants analyzed, 13 plants showed partial suppression of cpl2 phenotype. The true leaves of cpl2-2 35S-ARF5 expanded without exhibiting the characteristic epinasty of cpl2 seedlings (Fig. 9b

Ueda A, Li P, Feng Y, Vikram M, Kim S, Kang CH, Kang JS, Bahk JD, Lee SY, Fukuhara T, Staswick PE, Pepper AE, Koiwa H - The Arabidopsis thaliana carboxyl-terminal domain phosphatase-like 2 regulates plant growth, stress and auxin responses

• Genetic Interaction

as2–5D suppresses the morphological defects produced by continuous DEX treatment of 35S:KAN1-GR plants

Wu G, Lin WC, Huang T, Poethig RS, Springer PS, Kerstetter RA - KANADI1 regulates adaxial-abaxial polarity in Arabidopsis by directly repressing the transcription of ASYMMETRIC LEAVES2

• Genetic Interaction

Repression of KAN genes by AS2 is further supported by the phenotype of plants doubly mutant for kan1–11 and as2–5D (Fig. 7 I and M). Leaves of these double mutants display abaxial outgrowths that are a characteristic feature of kan1 kan2 double mutants (Fig. 7 J and N) but are not present in either kan1 (Fig. 7 G and K) or as2–5D single mutants (Fig. 7 H and L); that is, kan-11 as2–5D plants resemble kan1 kan2 double mutants. A

Wu G, Lin WC, Huang T, Poethig RS, Springer PS, Kerstetter RA - KANADI1 regulates adaxial-abaxial polarity in Arabidopsis by directly repressing the transcription of ASYMMETRIC LEAVES2

• Genetic Interaction

tfl1-1 appears phenotypically epistatic to emb1611-2 in the primary SAM

Leasure CD, Fiume E, Fletcher JC - The essential gene EMB1611 maintains shoot apical meristem function during Arabidopsis development

• Genetic Interaction

The herk1 the1 double mutant enhanced the bri1-5 dwarf phenotype

Guo H, Li L, Ye H, Yu X, Algreen A, Yin Y - Three related receptor-like kinases are required for optimal cell elongation in Arabidopsis thaliana

• Genetic Interaction

The herk1 the1 double mutant partially suppressed the cell elongation phenotype of bes1-D

Guo H, Li L, Ye H, Yu X, Algreen A, Yin Y - Three related receptor-like kinases are required for optimal cell elongation in Arabidopsis thaliana

• Genetic Interaction

oli2 ... and an3 have synergistic genetic interactions

Fujikura U, Horiguchi G, Ponce MR, Micol JL, Tsukaya H - Coordination of cell proliferation and cell expansion mediated by ribosome-related processes in the leaves of Arabidopsis thaliana

• Genetic Interaction

oli7 ... and an3 have synergistic genetic interactions

Fujikura U, Horiguchi G, Ponce MR, Micol JL, Tsukaya H - Coordination of cell proliferation and cell expansion mediated by ribosome-related processes in the leaves of Arabidopsis thaliana

• Genetic Interaction

oli5 ... and an3 have synergistic genetic interactions

Fujikura U, Horiguchi G, Ponce MR, Micol JL, Tsukaya H - Coordination of cell proliferation and cell expansion mediated by ribosome-related processes in the leaves of Arabidopsis thaliana

• Genetic Interaction

bin2-3bil2bri1-5 mutants are larger than the parental bin2-3bri1-5 double mutant ... revealing that suppression of the bri1-5 phenotype by bin2-3 can be significantly enhanced by elimination of ... BIL2

Yan Z, Zhao J, Peng P, Chihara RK, Li J - BIN2 functions redundantly with other Arabidopsis GSK3-like kinases to regulate brassinosteroid signaling

• Genetic Interaction

bin2-3bil1bri1-5 ... mutants are larger than the parental bin2-3bri1-5 double mutant ... revealing that suppression of the bri1-5 phenotype by bin2-3 can be significantly enhanced by elimination of ... BIL1

Yan Z, Zhao J, Peng P, Chihara RK, Li J - BIN2 functions redundantly with other Arabidopsis GSK3-like kinases to regulate brassinosteroid signaling

• Genetic Interaction

bin2-3bri1-5 double mutant has a bigger rosette with visible petioles and flatter leaves than the bri1-5 mutant. The partial suppression of bri1-5 by loss of BIN2 activity

Yan Z, Zhao J, Peng P, Chihara RK, Li J - BIN2 functions redundantly with other Arabidopsis GSK3-like kinases to regulate brassinosteroid signaling

• Genetic Interaction

er may be epistatic to epf2-1 with respect to stomatal density

Hunt L, Gray JE - The signaling peptide EPF2 controls asymmetric cell divisions during stomatal development

• Genetic Interaction

EPF2 overexpression in ... yda failed to decrease the density of stomata

Hara K, Yokoo T, Kajita R, Onishi T, Yahata S, Peterson KM, Torii KU, Kakimoto T - Epidermal cell density is autoregulated via a secretory peptide, EPIDERMAL PATTERNING FACTOR 2 in Arabidopsis leaves

• Genetic Interaction

the effects of epf1 and epf2 mutations on stomatal density were additive

Hara K, Yokoo T, Kajita R, Onishi T, Yahata S, Peterson KM, Torii KU, Kakimoto T - Epidermal cell density is autoregulated via a secretory peptide, EPIDERMAL PATTERNING FACTOR 2 in Arabidopsis leaves

• Genetic Interaction

EPF2 overexpression in ... er;erl1;erl2 ... failed to decrease the density of stomata

Hara K, Yokoo T, Kajita R, Onishi T, Yahata S, Peterson KM, Torii KU, Kakimoto T - Epidermal cell density is autoregulated via a secretory peptide, EPIDERMAL PATTERNING FACTOR 2 in Arabidopsis leaves

• Genetic Interaction

EPF2 overexpression in tmm ... failed to decrease the density of stomata

Hara K, Yokoo T, Kajita R, Onishi T, Yahata S, Peterson KM, Torii KU, Kakimoto T - Epidermal cell density is autoregulated via a secretory peptide, EPIDERMAL PATTERNING FACTOR 2 in Arabidopsis leaves

• Genetic Interaction

The degree of stomatal clustering of epf1;epf2 remained similar to that of epf1

Hara K, Yokoo T, Kajita R, Onishi T, Yahata S, Peterson KM, Torii KU, Kakimoto T - Epidermal cell density is autoregulated via a secretory peptide, EPIDERMAL PATTERNING FACTOR 2 in Arabidopsis leaves

• Genetic Interaction

The er;erl1;erl2;epf1;epf2 pentuple loss-of-function mutants exhibited stomatal density similar to er;erl1;erl2

Hara K, Yokoo T, Kajita R, Onishi T, Yahata S, Peterson KM, Torii KU, Kakimoto T - Epidermal cell density is autoregulated via a secretory peptide, EPIDERMAL PATTERNING FACTOR 2 in Arabidopsis leaves

• Genetic Interaction

The stomatal density of epf1;epf2;tmm was similar to that of tmm

Hara K, Yokoo T, Kajita R, Onishi T, Yahata S, Peterson KM, Torii KU, Kakimoto T - Epidermal cell density is autoregulated via a secretory peptide, EPIDERMAL PATTERNING FACTOR 2 in Arabidopsis leaves

• Genetic Interaction

The kaktus mutant also displays increased branch numbers of trichomes as a result of increased ploidy levels. A double mutant generated by crossing rpt2a with kaktus (rpt2a kak) showed an additive branching phenotype

Sonoda Y, Sako K, Maki Y, Yamazaki N, Yamamoto H, Ikeda A, Yamaguchi J - Regulation of leaf organ size by the Arabidopsis RPT2a 19S proteasome subunit

• Genetic Interaction

To investigate whether AIL6 function overlaps with that of ANT, the strong ant-4 allele in the Landsberg erecta (Ler) background (Baker et al., 1997; Nole-Wilson and Krizek, 2006) was crossed to all four ail6 alleles. All of these double mutants displayed a similar enhanced phenotype compared with ant-4 single mutants (Fig. 1, L–O). This double mutant phenotype is not significantly affected by the mixed Col/Ler background (Supplemental Fig. S1

Krizek B - AINTEGUMENTA and AINTEGUMENTA-LIKE6 act redundantly to regulate Arabidopsis floral growth and patterning

• Genetic Interaction

This suggests that the branch elongation defect seen in zwichel mutants was enhanced in the tor2 zwichel double mutant background

Buschmann H, Hauptmann M, Niessing D, Lloyd CW, Schäffner AR - Helical growth of the Arabidopsis mutant tortifolia2 does not depend on cell division patterns but involves handed twisting of isolated cells

• Genetic Interaction

The tor1 tor2 double mutant clearly shows an additive leaf twisting phenotype

Buschmann H, Hauptmann M, Niessing D, Lloyd CW, Schäffner AR - Helical growth of the Arabidopsis mutant tortifolia2 does not depend on cell division patterns but involves handed twisting of isolated cells

• Genetic Interaction

tor2 zwichel double mutant trichomes often showed an enhancement of the right-handed twisting seen in the tor2 background

Buschmann H, Hauptmann M, Niessing D, Lloyd CW, Schäffner AR - Helical growth of the Arabidopsis mutant tortifolia2 does not depend on cell division patterns but involves handed twisting of isolated cells

• Genetic Interaction

The tor2 zwichel double mutant shows significantly more branch points when compared with the zwichel single mutant

Buschmann H, Hauptmann M, Niessing D, Lloyd CW, Schäffner AR - Helical growth of the Arabidopsis mutant tortifolia2 does not depend on cell division patterns but involves handed twisting of isolated cells

• Genetic Interaction

the leaf lamina of the as1-1 knat2-3 knat6-2 triple mutant was significantly longer than that of the as1-1 mutant, and was as long as that of the wild type

Ikezaki M, Kojima M, Sakakibara H, Kojima S, Ueno Y, Machida C, Machida Y - Genetic networks regulated by ASYMMETRIC LEAVES1 (AS1) and AS2 in leaf development in Arabidopsis thaliana: KNOX genes control five morphological events

• Genetic Interaction

The petioles of the as1-1 knat2-3 knat6-2 triple mutant were slightly longer than those of the as1-1 mutant

Ikezaki M, Kojima M, Sakakibara H, Kojima S, Ueno Y, Machida C, Machida Y - Genetic networks regulated by ASYMMETRIC LEAVES1 (AS1) and AS2 in leaf development in Arabidopsis thaliana: KNOX genes control five morphological events

• Genetic Interaction

The petioles of the as2-1 bp-1 knat2-3 knat6-2 quadruple mutant were slightly longer than those of the as2-1 mutant, but the shortened-lamina phenotype was not rescued

Ikezaki M, Kojima M, Sakakibara H, Kojima S, Ueno Y, Machida C, Machida Y - Genetic networks regulated by ASYMMETRIC LEAVES1 (AS1) and AS2 in leaf development in Arabidopsis thaliana: KNOX genes control five morphological events

• Genetic Interaction

In as1-1 bp-1 ... leaves, larger numbers of secondary veins connected to the midvein in the lamina than they did in the as1-1 single mutant ... Thus, a prominent midvein was restored in each multiple mutant. These results suggest that the less prominent midveins in as1 and as2 leaves might be caused by the ectopic expression of KNAT126

Ikezaki M, Kojima M, Sakakibara H, Kojima S, Ueno Y, Machida C, Machida Y - Genetic networks regulated by ASYMMETRIC LEAVES1 (AS1) and AS2 in leaf development in Arabidopsis thaliana: KNOX genes control five morphological events

• Genetic Interaction

The shapes of as1-1 bp-10 double-mutant leaves were similar to those of as1-1 bp-1 leaves (Figure 1h,i; ex2), indicating that the phenotype of as1-1 bp-1 leaves was caused by the mutation in BP

Ikezaki M, Kojima M, Sakakibara H, Kojima S, Ueno Y, Machida C, Machida Y - Genetic networks regulated by ASYMMETRIC LEAVES1 (AS1) and AS2 in leaf development in Arabidopsis thaliana: KNOX genes control five morphological events

• Genetic Interaction

In as1-1 bp-1, as1-1 knat2-3 knat6-2 and as1-1 bp-1 knat2-3 knat6-2 leaves, larger numbers of secondary veins connected to the midvein in the lamina than they did in the as1-1 single mutant (Figure 4a-e,h). The as2-1 bp-1 knat2-3 knat6-2 leaves had a similar phenotype (Figure 4a,f-h). Thus, a prominent midvein was restored in each multiple mutant. These results suggest that the less prominent midveins in as1 and as2 leaves might be caused by the ectopic expression of KNAT126

Ikezaki M, Kojima M, Sakakibara H, Kojima S, Ueno Y, Machida C, Machida Y - Genetic networks regulated by ASYMMETRIC LEAVES1 (AS1) and AS2 in leaf development in Arabidopsis thaliana: KNOX genes control five morphological events

• Genetic Interaction

The petioles and leaf blades of the as1-1 mutant were shorter than those of the wild type (Figure 1a,g,h). When we introduced the bp-1 mutation into as1-1 plants, lengths of the petioles of the as1-1 bp-1 double mutant increased significantly, but the petioles were still shorter than the wild type (Figure 1a,b,h

Ikezaki M, Kojima M, Sakakibara H, Kojima S, Ueno Y, Machida C, Machida Y - Genetic networks regulated by ASYMMETRIC LEAVES1 (AS1) and AS2 in leaf development in Arabidopsis thaliana: KNOX genes control five morphological events

• Genetic Interaction

We measured the lengths of the epidermal cells in petioles from wild-type plants, as1-1 mutant plants and as1-1 bp-1 knat2-3 knat6-2 quadruple mutant plants along the proximodistal axis. The epidermal cells of the as1-1 petiole were shorter than those of the wild-type petiole (Figure 1j,k,m). The lengths of epidermal cells in the petiole from the as1-1 bp-1 knat2-3 knat6-2 quadruple mutant were indistinguishable from those of the wild type (Figure 1j,l,m

Ikezaki M, Kojima M, Sakakibara H, Kojima S, Ueno Y, Machida C, Machida Y - Genetic networks regulated by ASYMMETRIC LEAVES1 (AS1) and AS2 in leaf development in Arabidopsis thaliana: KNOX genes control five morphological events

• Genetic Interaction

the leaf lamina of the as1-1 bp-1 knat2-3 knat6-2 quadruple mutant was slightly longer than that of the as1-1 mutant, but was shorter than that of the wild type

Ikezaki M, Kojima M, Sakakibara H, Kojima S, Ueno Y, Machida C, Machida Y - Genetic networks regulated by ASYMMETRIC LEAVES1 (AS1) and AS2 in leaf development in Arabidopsis thaliana: KNOX genes control five morphological events

• Genetic Interaction

In ... as1-1 knat2-3 knat6-2 ... leaves, larger numbers of secondary veins connected to the midvein in the lamina than they did in the as1-1 ... Thus, a prominent midvein was restored in each multiple mutant. These results suggest that the less prominent midveins in as1 and as2 leaves might be caused by the ectopic expression of KNAT126

Ikezaki M, Kojima M, Sakakibara H, Kojima S, Ueno Y, Machida C, Machida Y - Genetic networks regulated by ASYMMETRIC LEAVES1 (AS1) and AS2 in leaf development in Arabidopsis thaliana: KNOX genes control five morphological events

• Genetic Interaction

The leaves of the as1-1 bp-1 knat2-3 knat6-2 quadruple mutant had longer petioles than those of the as1-1 bp-1 double mutant (Figure 1b,d,h), even though they were still shorter than those of the wild type

Ikezaki M, Kojima M, Sakakibara H, Kojima S, Ueno Y, Machida C, Machida Y - Genetic networks regulated by ASYMMETRIC LEAVES1 (AS1) and AS2 in leaf development in Arabidopsis thaliana: KNOX genes control five morphological events

• Genetic Interaction

Introduction of the spy-1 mutation, which generates constitutive GA signaling, into the as1 mutant resulted in the generation of longer petioles (Figure S2a-c), suggesting the epistatic effect of spy-1 on the formation of petioles

Ikezaki M, Kojima M, Sakakibara H, Kojima S, Ueno Y, Machida C, Machida Y - Genetic networks regulated by ASYMMETRIC LEAVES1 (AS1) and AS2 in leaf development in Arabidopsis thaliana: KNOX genes control five morphological events

• Genetic Interaction

In ... as1-1 bp-1 knat2-3 knat6-2 leaves, larger numbers of secondary veins connected to the midvein in the lamina than they did in the as1-1 single mutant ... Thus, a prominent midvein was restored in each multiple mutant. These results suggest that the less prominent midveins in as1 and as2 leaves might be caused by the ectopic expression of KNAT126

Ikezaki M, Kojima M, Sakakibara H, Kojima S, Ueno Y, Machida C, Machida Y - Genetic networks regulated by ASYMMETRIC LEAVES1 (AS1) and AS2 in leaf development in Arabidopsis thaliana: KNOX genes control five morphological events

• Genetic Interaction

vein patterns ... SSRP1 ... act epistatically to HUB1 ... 2

Lolas IB, Himanen K, Grønlund JT, Lynggaard C, Houben A, Melzer M, Van Lijsebettens M, Grasser KD - The transcript elongation factor FACT affects Arabidopsis vegetative and reproductive development and genetically interacts with HUB1/2

• Genetic Interaction

synergistic effects for SSRP1 ... and HUB1 ... on leaf growth (Figure S2a and Table S1). Thus, for leaf growth, SSRP1/SPT16 and HUB1/2 act independently on the same pathway(s), but may share redundant functions or target genes

Lolas IB, Himanen K, Grønlund JT, Lynggaard C, Houben A, Melzer M, Van Lijsebettens M, Grasser KD - The transcript elongation factor FACT affects Arabidopsis vegetative and reproductive development and genetically interacts with HUB1/2

• Genetic Interaction

leaf shape ... SSRP1 ... act epistatically to HUB1

Lolas IB, Himanen K, Grønlund JT, Lynggaard C, Houben A, Melzer M, Van Lijsebettens M, Grasser KD - The transcript elongation factor FACT affects Arabidopsis vegetative and reproductive development and genetically interacts with HUB1/2

• Genetic Interaction

vein patterns ... SPT16 act epistatically to HUB1

Lolas IB, Himanen K, Grønlund JT, Lynggaard C, Houben A, Melzer M, Van Lijsebettens M, Grasser KD - The transcript elongation factor FACT affects Arabidopsis vegetative and reproductive development and genetically interacts with HUB1/2

• Genetic Interaction

leaf shape ... SPT16 act epistatically to HUB1

Lolas IB, Himanen K, Grønlund JT, Lynggaard C, Houben A, Melzer M, Van Lijsebettens M, Grasser KD - The transcript elongation factor FACT affects Arabidopsis vegetative and reproductive development and genetically interacts with HUB1/2

• Genetic Interaction

synergistic effects for ... SPT16 and HUB1 ... on leaf growth (Figure S2a and Table S1). Thus, for leaf growth, SSRP1/SPT16 and HUB1/2 act independently on the same pathway(s), but may share redundant functions or target genes

Lolas IB, Himanen K, Grønlund JT, Lynggaard C, Houben A, Melzer M, Van Lijsebettens M, Grasser KD - The transcript elongation factor FACT affects Arabidopsis vegetative and reproductive development and genetically interacts with HUB1/2

• Genetic Interaction

vein patterns ... SSRP1 ... act epistatically to HUB1

Lolas IB, Himanen K, Grønlund JT, Lynggaard C, Houben A, Melzer M, Van Lijsebettens M, Grasser KD - The transcript elongation factor FACT affects Arabidopsis vegetative and reproductive development and genetically interacts with HUB1/2

• Genetic Interaction

synergistic effects for ... SPT16 and HUB ... 2 on leaf growth (Figure S2a and Table S1). Thus, for leaf growth, SSRP1/SPT16 and HUB1/2 act independently on the same pathway(s), but may share redundant functions or target genes

Lolas IB, Himanen K, Grønlund JT, Lynggaard C, Houben A, Melzer M, Van Lijsebettens M, Grasser KD - The transcript elongation factor FACT affects Arabidopsis vegetative and reproductive development and genetically interacts with HUB1/2

• Genetic Interaction

synergistic effects for SSRP1 ... and HUB ... 2 on leaf growth (Figure S2a and Table S1). Thus, for leaf growth, SSRP1/SPT16 and HUB1/2 act independently on the same pathway(s), but may share redundant functions or target genes

Lolas IB, Himanen K, Grønlund JT, Lynggaard C, Houben A, Melzer M, Van Lijsebettens M, Grasser KD - The transcript elongation factor FACT affects Arabidopsis vegetative and reproductive development and genetically interacts with HUB1/2

• Genetic Interaction

vein patterns ... SPT16 act epistatically to HUB ... 2

Lolas IB, Himanen K, Grønlund JT, Lynggaard C, Houben A, Melzer M, Van Lijsebettens M, Grasser KD - The transcript elongation factor FACT affects Arabidopsis vegetative and reproductive development and genetically interacts with HUB1/2

• Genetic Interaction

leaf shape ... SPT16 act epistatically to HUB ... 2

Lolas IB, Himanen K, Grønlund JT, Lynggaard C, Houben A, Melzer M, Van Lijsebettens M, Grasser KD - The transcript elongation factor FACT affects Arabidopsis vegetative and reproductive development and genetically interacts with HUB1/2

• Genetic Interaction

leaf shape ... SSRP1 ... act epistatically to HUB ... 2

Lolas IB, Himanen K, Grønlund JT, Lynggaard C, Houben A, Melzer M, Van Lijsebettens M, Grasser KD - The transcript elongation factor FACT affects Arabidopsis vegetative and reproductive development and genetically interacts with HUB1/2

• Genetic Interaction

mild increase in TCP4 levels in soj8 (Fig. 7C) caused ... reduction in leaf size

Rodriguez RE, Mecchia MA, Debernardi JM, Schommer C, Weigel D, Palatnik JF - Control of cell proliferation in Arabidopsis thaliana by microRNA miR396

• Genetic Interaction

The reduction in leaf size caused by miR396 overexpression was suppressed by the introduction of rGRF2

Rodriguez RE, Mecchia MA, Debernardi JM, Schommer C, Weigel D, Palatnik JF - Control of cell proliferation in Arabidopsis thaliana by microRNA miR396

• Genetic Interaction

mild increase in TCP4 levels in soj8 (Fig. 7C) caused a reduction in cell number

Rodriguez RE, Mecchia MA, Debernardi JM, Schommer C, Weigel D, Palatnik JF - Control of cell proliferation in Arabidopsis thaliana by microRNA miR396

• Genetic Interaction

we overexpressed miR396 in the context of a grf5 insertional mutant ... and their leaves were smaller ... reflecting synergistic effects between the 35S:miR396b transgene and grf5

Rodriguez RE, Mecchia MA, Debernardi JM, Schommer C, Weigel D, Palatnik JF - Control of cell proliferation in Arabidopsis thaliana by microRNA miR396

• Genetic Interaction

Analysis of the CYCB1;1 reporter in soj8 confirmed a reduction in the number of cycling cells

Rodriguez RE, Mecchia MA, Debernardi JM, Schommer C, Weigel D, Palatnik JF - Control of cell proliferation in Arabidopsis thaliana by microRNA miR396

• Genetic Interaction

NULL

Rodriguez RE, Mecchia MA, Debernardi JM, Schommer C, Weigel D, Palatnik JF - Control of cell proliferation in Arabidopsis thaliana by microRNA miR396

• Genetic Interaction

we overexpressed miR396 in the context of a grf5 insertional mutant ... and their leaves were ... narrower ... reflecting synergistic effects between the 35S:miR396b transgene and grf5

Rodriguez RE, Mecchia MA, Debernardi JM, Schommer C, Weigel D, Palatnik JF - Control of cell proliferation in Arabidopsis thaliana by microRNA miR396

• Genetic Interaction

we overexpressed miR396 in an3-1 and observed that half of the 35S:miR396b an3-1 plants (48 out of 90 independent T1s) lacked a functional SAM

Rodriguez RE, Mecchia MA, Debernardi JM, Schommer C, Weigel D, Palatnik JF - Control of cell proliferation in Arabidopsis thaliana by microRNA miR396

• Genetic Interaction

These results suggest that an3-4 spt-11 double mutations exert an additive effect on the cellular phenotype of leaves

Ichihashi Y, Horiguchi G, Gleissberg S, Tsukaya H - The bHLH transcription factor SPATULA controls final leaf size in Arabidopsis thaliana

• Genetic Interaction

The number of branching points per mm2 ... were similar in cvp2-1 ... suggesting that the cvp2-1 mutation is epistatic on ron1-2

Robles P, Fleury D, Candela H, Cnops G, Alonso-Peral MM, Anami S, Falcone A, Caldana C, Willmitzer L, Ponce MR, Van Lijsebettens M, Micol JL - The RON1/FRY1/SAL1 gene is required for leaf morphogenesis and venation patterning in Arabidopsis

• Genetic Interaction

ron1-2 hve-2 ... venation pattern defects were ... greatly enhanced in the leaves of these double mutants

Robles P, Fleury D, Candela H, Cnops G, Alonso-Peral MM, Anami S, Falcone A, Caldana C, Willmitzer L, Ponce MR, Van Lijsebettens M, Micol JL - The RON1/FRY1/SAL1 gene is required for leaf morphogenesis and venation patterning in Arabidopsis

• Genetic Interaction

the number of free-ending veins per unit venation length in ron1-2 cvp1-3 leaves ... was intermediate to those of ron1-2 ... and cvp1-3

Robles P, Fleury D, Candela H, Cnops G, Alonso-Peral MM, Anami S, Falcone A, Caldana C, Willmitzer L, Ponce MR, Van Lijsebettens M, Micol JL - The RON1/FRY1/SAL1 gene is required for leaf morphogenesis and venation patterning in Arabidopsis

• Genetic Interaction

Venation density was slightly but significantly reduced in the ron1-2 cvp2-1

Robles P, Fleury D, Candela H, Cnops G, Alonso-Peral MM, Anami S, Falcone A, Caldana C, Willmitzer L, Ponce MR, Van Lijsebettens M, Micol JL - The RON1/FRY1/SAL1 gene is required for leaf morphogenesis and venation patterning in Arabidopsis

• Genetic Interaction

the venation pattern of the ron1-2 cvp1-3 double mutant was less open than that of ron1-1

Robles P, Fleury D, Candela H, Cnops G, Alonso-Peral MM, Anami S, Falcone A, Caldana C, Willmitzer L, Ponce MR, Van Lijsebettens M, Micol JL - The RON1/FRY1/SAL1 gene is required for leaf morphogenesis and venation patterning in Arabidopsis

• Genetic Interaction

ron1-2 axr1-12 ... venation pattern defects were ... greatly enhanced in the leaves of these double mutants

Robles P, Fleury D, Candela H, Cnops G, Alonso-Peral MM, Anami S, Falcone A, Caldana C, Willmitzer L, Ponce MR, Van Lijsebettens M, Micol JL - The RON1/FRY1/SAL1 gene is required for leaf morphogenesis and venation patterning in Arabidopsis

• Genetic Interaction

The synergistic effects of the etg1 and ... syn4 on cell division

Takahashi N, Quimbaya M, Schubert V, Lammens T, Vandepoele K, Schubert I, Matsui M, Inzé D, Berx G, De Veylder L - The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair

• Genetic Interaction

The synergistic effects of the etg1 and the cohesion mutants ctf18 ... on cell division

Takahashi N, Quimbaya M, Schubert V, Lammens T, Vandepoele K, Schubert I, Matsui M, Inzé D, Berx G, De Veylder L - The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair

• Genetic Interaction

that BASL and EPF2 operate independently to regulate asymmetric divisions during stomatal development

Hunt L, Gray JE - BASL and EPF2 act independently to regulate asymmetric divisions during stomatal development

• Genetic Interaction

rps6a,rps6b double mutant ... is lethal

Creff A, Sormani R, Desnos T - The two Arabidopsis RPS6 genes, encoding for cytoplasmic ribosomal proteins S6, are functionally equivalent

• Genetic Interaction

introduction of the bp knat2 knat6 allele combination caused a more dramatic suppression of the bop1 bop2 leaf phenotype

Ha CM, Jun JH, Fletcher JC - Control of Arabidopsis leaf morphogenesis through regulation of the YABBY and KNOX families of transcription factors

• Genetic Interaction

mutations in ... FIL ... partially suppressed the ... leaf phenotype ... bop1 bop2

Ha CM, Jun JH, Fletcher JC - Control of Arabidopsis leaf morphogenesis through regulation of the YABBY and KNOX families of transcription factors

• Genetic Interaction

Developing wild-type rosette leaf petioles displayed a fully differentiated cellular morphology (Figure 1F), as did bp knat2 knat6 petioles (Figure 1H). In contrast, bop1 bop2 petioles had small and undifferentiated cells at the margins, where the ectopic outgrowths formed (Figure 1G, arrows). The introduction of the knat6 allele into the bop1 bop2 background caused a slight suppression of ectopic outgrowth at the cellular level

Ha CM, Jun JH, Fletcher JC - Control of Arabidopsis leaf morphogenesis through regulation of the YABBY and KNOX families of transcription factors

• Genetic Interaction

mutations in ... YAB3 partially suppressed the ... leaf phenotype ... bop1 bop2

Ha CM, Jun JH, Fletcher JC - Control of Arabidopsis leaf morphogenesis through regulation of the YABBY and KNOX families of transcription factors

• Genetic Interaction

The addition of ... the knat2 ... allele into the bop1 bop2 fil yab3 background slightly suppressed the leaf phenotype

Ha CM, Jun JH, Fletcher JC - Control of Arabidopsis leaf morphogenesis through regulation of the YABBY and KNOX families of transcription factors

• Genetic Interaction

We then introduced the knat2 knat6 ... alleles into the bop1 bop2 fil yab3 background. All hextuple mutants showed suppression of the bop1 bop2 fil yab3 leaf phenotypes

Ha CM, Jun JH, Fletcher JC - Control of Arabidopsis leaf morphogenesis through regulation of the YABBY and KNOX families of transcription factors

• Genetic Interaction

We then introduced the ... bp knat6 alleles into the bop1 bop2 fil yab3 background. All hextuple mutants showed suppression of the bop1 bop2 fil yab3 leaf phenotypes

Ha CM, Jun JH, Fletcher JC - Control of Arabidopsis leaf morphogenesis through regulation of the YABBY and KNOX families of transcription factors

• Genetic Interaction

Introduction of the ... yab3 ... into bop1 bop2 bp knat2 knat6 plants induced further suppression of the leaf phenotypes

Ha CM, Jun JH, Fletcher JC - Control of Arabidopsis leaf morphogenesis through regulation of the YABBY and KNOX families of transcription factors

• Genetic Interaction

bop1 bop2 knat6 leaves developed reduced ectopic blade outgrowths in their petiole region (Figure 1D) compared to bop1 bop2 leaves. Whereas all bop1 bop2 bp, bop1 bop2 knat2, and bop1 bop2 bp knat2 plants displayed a class I leaf phenotype, ∼28% of bop1 bop2 knat6 plants displayed a class II leaf phenotype (Figure 3A), showing that mutating KNAT6 slightly suppresses the bop1 bop2 phenotype. bop1 bop2 bp knat6 and bop1 bop2 knat2 knat6 leaves had slightly milder phenotypes than bop1 bop2 knat6 leaves. Class II leaf phenotypes appeared in 41% of bop1 bop2 bp knat6 plants and in 57% of bop1 bop2 knat2 knat6 plants (Figure 3A). In bop1 bop2 bp knat2 knat6 leaves the extent of ectopic outgrowth was further reduced (Figure 1E), with 67% of bop1 bop2 bp knat2 knat6 leaves displaying class II phenotypes (Figure 3A) and some developing ectopic outgrowths along only one side of the petiole

Ha CM, Jun JH, Fletcher JC - Control of Arabidopsis leaf morphogenesis through regulation of the YABBY and KNOX families of transcription factors

• Genetic Interaction

We then introduced the ... bp knat2 ... alleles into the bop1 bop2 fil yab3 background. All hextuple mutants showed suppression of the bop1 bop2 fil yab3 leaf phenotypes

Ha CM, Jun JH, Fletcher JC - Control of Arabidopsis leaf morphogenesis through regulation of the YABBY and KNOX families of transcription factors

• Genetic Interaction

Introduction of the fil ... into bop1 bop2 bp knat2 knat6 plants induced further suppression of the leaf phenotypes

Ha CM, Jun JH, Fletcher JC - Control of Arabidopsis leaf morphogenesis through regulation of the YABBY and KNOX families of transcription factors

• Genetic Interaction

The addition of ... the knat6 allele into the bop1 bop2 fil yab3 background slightly suppressed the leaf phenotype

Ha CM, Jun JH, Fletcher JC - Control of Arabidopsis leaf morphogenesis through regulation of the YABBY and KNOX families of transcription factors

• Genetic Interaction

The above results showed that the cotyledon chlorosis is dependent on SIG6 transcripts levels in the dg1 mutant background (Figure 6a). We suspected that the enhancement of SIG6 may rescue the chlorosis of dg1 mutants. To check this, SIG6 was overexpressed in dg1 plants under the control of the CaMV 35S promoter, and 11 independent transformants were obtained. Three representative 35S:SIG6 dg1 lines were shown in which cotyledon chlorosis was rescued

Chi W, Mao J, Li Q, Ji D, Zou M, Lu C, Zhang L - Interaction of the pentatricopeptide-repeat protein DELAYED GREENING 1 with sigma factor SIG6 in the regulation of chloroplast gene expression in Arabidopsis cotyledons

• Genetic Interaction

The leaves of axr1-12 icu6/axr1-12 AXR3 plants were indistinguishable from those of their axr1-12 AXR3/axr1-12 AXR3 siblings (Fig. 4M), indicating that axr1-12 is epistatic to icu6 with regard to leaf development, which suggests that the AXR1 protein acts upstream of AXR3

Pérez-Pérez JM, Candela H, Robles P, López-Torrejón G, del Pozo JC, Micol JL - A role for AUXIN RESISTANT3 in the coordination of leaf growth

• Genetic Interaction

The Dof5.1-D/35S::miR165 and Dof5.1-D/35S::ZPR4 plants showed a similar phenotype to the 35S::miR165 and 35S::ZPR4 plants (Kim et al., 2005; Byrne, 2006; Wenkel et al., 2007), having downward-curled leaves (Figure 7a,b). This genetic evidence indicates that 35S::miR165 and 35::ZPR4 suppress the Dof5.1-D upward-curling phenotype

Kim HS, Kim SJ, Abbasi N, Bressan RA, Yun DJ, Yoo SD, Kwon SY, Choi SB - The DOF transcription factor Dof5.1 influences leaf axial patterning by promoting Revoluta transcription in Arabidopsis

• Genetic Interaction

The Dof5.1-D/35S::miR165 and Dof5.1-D/35S::ZPR4 plants showed a similar phenotype to the 35S::miR165 and 35S::ZPR4 plants (Kim et al., 2005; Byrne, 2006; Wenkel et al., 2007), having downward-curled leaves (Figure 7a,b). This genetic evidence indicates that 35S::miR165 and 35::ZPR4 suppress the Dof5.1-D upward-curling phenotype

Kim HS, Kim SJ, Abbasi N, Bressan RA, Yun DJ, Yoo SD, Kwon SY, Choi SB - The DOF transcription factor Dof5.1 influences leaf axial patterning by promoting Revoluta transcription in Arabidopsis

• Genetic Interaction

The resulting Dof5.1-D/rev plants lacked the upward-curling phenotype of Dof5.1-D, thereby displaying almost WT morphology

Kim HS, Kim SJ, Abbasi N, Bressan RA, Yun DJ, Yoo SD, Kwon SY, Choi SB - The DOF transcription factor Dof5.1 influences leaf axial patterning by promoting Revoluta transcription in Arabidopsis

• Genetic Interaction

ae7 ago7-3 ... showed enhanced defects in leaf adaxial identity, with an increased number of needle-like leaves

Yuan Z, Luo D, Li G, Yao X, Wang H, Zeng M, Huang H, Cui X - Characterization of the AE7 gene in Arabidopsis suggests that normal cell proliferation is essential for leaf polarity establishment

• Genetic Interaction

From M2 progeny of the EMS-mutagenized as2-101 plants, a mutant plant showing an enhanced as2 phenotype with an increased number of needle-like leaves was identified ... The segregation ratio suggested that the new phenotypes might be caused by a new mutation linked to the as2 locus and this was designated ae7 (as1/2 enhancer7)

Yuan Z, Luo D, Li G, Yao X, Wang H, Zeng M, Huang H, Cui X - Characterization of the AE7 gene in Arabidopsis suggests that normal cell proliferation is essential for leaf polarity establishment

• Genetic Interaction

ae7 rdr6-3 ... showed enhanced defects in leaf adaxial identity, with an increased number of needle-like leaves

Yuan Z, Luo D, Li G, Yao X, Wang H, Zeng M, Huang H, Cui X - Characterization of the AE7 gene in Arabidopsis suggests that normal cell proliferation is essential for leaf polarity establishment

• Genetic Interaction

ae7 as1-101 ... showed enhanced defects in leaf adaxial identity, with an increased number of needle-like leaves

Yuan Z, Luo D, Li G, Yao X, Wang H, Zeng M, Huang H, Cui X - Characterization of the AE7 gene in Arabidopsis suggests that normal cell proliferation is essential for leaf polarity establishment

• Genetic Interaction

mutation of ... SYP23 in syp22 additively enhanced the growth defects

Shirakawa M, Ueda H, Shimada T, Koumoto Y, Shimada TL, Kondo M, Takahashi T, Okuyama Y, Nishimura M, Hara-Nishimura I - Arabidopsis Qa-SNARE SYP2 proteins localized to different subcellular regions function redundantly in vacuolar protein sorting and plant development

• Genetic Interaction

A mutation of SYP21 ... in syp22 additively enhanced the growth defects

Shirakawa M, Ueda H, Shimada T, Koumoto Y, Shimada TL, Kondo M, Takahashi T, Okuyama Y, Nishimura M, Hara-Nishimura I - Arabidopsis Qa-SNARE SYP2 proteins localized to different subcellular regions function redundantly in vacuolar protein sorting and plant development

• Genetic Interaction

double mutant AtNuc-L1 apum23-1 ... the additive effect

Abbasi N, Kim HB, Park NI, Kim HS, Kim YK, Park YI, Choi SB - APUM23, a nucleolar Puf domain protein, is involved in pre-ribosomal RNA processing and normal growth patterning in Arabidopsis

• Genetic Interaction

AtHAM4 Genetically Interacts with ... AtHAM2 in Promoting Shoot Indeterminacy

Engstrom EM, Andersen CM, Gumulak-Smith J, Hu J, Orlova E, Sozzani R, Bowman JL - Arabidopsis homologs of the petunia hairy meristem gene are required for maintenance of shoot and root indeterminacy

• Genetic Interaction

AtHAM4 Genetically Interacts with AtHAM1 ... in Promoting Shoot Indeterminacy

Engstrom EM, Andersen CM, Gumulak-Smith J, Hu J, Orlova E, Sozzani R, Bowman JL - Arabidopsis homologs of the petunia hairy meristem gene are required for maintenance of shoot and root indeterminacy

• Genetic Interaction

A single copy of rpl27ac-1d combined with ... as1 pgy2 resulted in non-additive leaf phenotypes

Szakonyi D, Byrne ME - Ribosomal protein L27a is required for growth and patterning in Arabidopsis thaliana

• Genetic Interaction

A single copy of rpl27ac-1d combined with ... as1 pgy1 ... resulted in non-additive leaf phenotypes

Szakonyi D, Byrne ME - Ribosomal protein L27a is required for growth and patterning in Arabidopsis thaliana

• Genetic Interaction

variable polarity ... defects ... in 13 poi as2-1 ... is variable. rps28b-1 (Figure 6a,g) and rps15ab-1 rpl28a-1 (Figure S4) are examples of weak enhancers, while the three rps6a alleles showed a strong enhancement of the leaf polarity defects caused by as2-1, as indicated by the fact that 80% of the double mutant leaves were filamentous

Horiguchi G, Mollá-Morales A, Pérez-Pérez JM, Kojima K, Robles P, Ponce MR, Micol JL, Tsukaya H - Differential contributions of ribosomal protein genes to Arabidopsis thaliana leaf development

• Genetic Interaction

poi ... as2-1 ... leaf ... rosettes showed variable polarity defects, ranging from weak (as-like leaves; Figure 6b) to mild (trumpet-like leaves; Figure 6c,d) or strong (needle-like or filamentous leaves

Horiguchi G, Mollá-Morales A, Pérez-Pérez JM, Kojima K, Robles P, Ponce MR, Micol JL, Tsukaya H - Differential contributions of ribosomal protein genes to Arabidopsis thaliana leaf development

• Genetic Interaction

den as2-1 double mutants displayed stronger leaf phenotypes

Horiguchi G, Mollá-Morales A, Pérez-Pérez JM, Kojima K, Robles P, Ponce MR, Micol JL, Tsukaya H - Differential contributions of ribosomal protein genes to Arabidopsis thaliana leaf development

• Genetic Interaction

Our results confirm that the rpl4d-3 mutation enhances the abaxialization phenotype of as2-1, probably by increasing the expression of abaxial determinants through an unknown, ribosome-related mechanism

Horiguchi G, Mollá-Morales A, Pérez-Pérez JM, Kojima K, Robles P, Ponce MR, Micol JL, Tsukaya H - Differential contributions of ribosomal protein genes to Arabidopsis thaliana leaf development

• Genetic Interaction

Leaves from the den as1-14 double mutants studied were smaller than those of any single mutant and shared traits with both parents

Horiguchi G, Mollá-Morales A, Pérez-Pérez JM, Kojima K, Robles P, Ponce MR, Micol JL, Tsukaya H - Differential contributions of ribosomal protein genes to Arabidopsis thaliana leaf development

• Genetic Interaction

poi ... as2-1 double mutants displayed stronger leaf phenotypes

Horiguchi G, Mollá-Morales A, Pérez-Pérez JM, Kojima K, Robles P, Ponce MR, Micol JL, Tsukaya H - Differential contributions of ribosomal protein genes to Arabidopsis thaliana leaf development

• Genetic Interaction

double mutants displayed stronger leaf phenotypes ... poi as1 ... - ... 1

Horiguchi G, Mollá-Morales A, Pérez-Pérez JM, Kojima K, Robles P, Ponce MR, Micol JL, Tsukaya H - Differential contributions of ribosomal protein genes to Arabidopsis thaliana leaf development

• Genetic Interaction

Inactivating MIR164A in the serrated mutant/transgenic lines suggested that ... UFOoexp ... contribute to leaf margin dissection independently of MIR164A

Hasson A, Plessis A, Blein T, Adroher B, Grigg S, Tsiantis M, Boudaoud A, Damerval C, Laufs P - Evolution and diverse roles of the CUP-SHAPED COTYLEDON genes in Arabidopsis leaf development

• Genetic Interaction

Inactivating MIR164A in the serrated mutant/transgenic lines suggested that jaw-D ... contribute to leaf margin dissection independently of MIR164A

Hasson A, Plessis A, Blein T, Adroher B, Grigg S, Tsiantis M, Boudaoud A, Damerval C, Laufs P - Evolution and diverse roles of the CUP-SHAPED COTYLEDON genes in Arabidopsis leaf development

• Genetic Interaction

Inactivating MIR164A in the serrated mutant/transgenic lines suggested that ... SE ... act via a pathway requiring MIR164A

Hasson A, Plessis A, Blein T, Adroher B, Grigg S, Tsiantis M, Boudaoud A, Damerval C, Laufs P - Evolution and diverse roles of the CUP-SHAPED COTYLEDON genes in Arabidopsis leaf development

• Genetic Interaction

double mutants with ... se-1 and cuc1-13 indicate that ... CUC1 does not contribute to leaf serration in ... se-1

Hasson A, Plessis A, Blein T, Adroher B, Grigg S, Tsiantis M, Boudaoud A, Damerval C, Laufs P - Evolution and diverse roles of the CUP-SHAPED COTYLEDON genes in Arabidopsis leaf development

• Genetic Interaction

Inactivating MIR164A in the serrated mutant/transgenic lines suggested that ... saw1 saw2 ... contribute to leaf margin dissection independently of MIR164A

Hasson A, Plessis A, Blein T, Adroher B, Grigg S, Tsiantis M, Boudaoud A, Damerval C, Laufs P - Evolution and diverse roles of the CUP-SHAPED COTYLEDON genes in Arabidopsis leaf development

• Genetic Interaction

double mutants with cbp20 ... and cuc1-13 ... indicate that ... CUC1 does not contribute to leaf serration in cbp20

Hasson A, Plessis A, Blein T, Adroher B, Grigg S, Tsiantis M, Boudaoud A, Damerval C, Laufs P - Evolution and diverse roles of the CUP-SHAPED COTYLEDON genes in Arabidopsis leaf development

• Genetic Interaction

Inactivating MIR164A in the serrated mutant/transgenic lines suggested that ... stip-D ... contribute to leaf margin dissection independently of MIR164A

Hasson A, Plessis A, Blein T, Adroher B, Grigg S, Tsiantis M, Boudaoud A, Damerval C, Laufs P - Evolution and diverse roles of the CUP-SHAPED COTYLEDON genes in Arabidopsis leaf development

• Genetic Interaction

UFOoexp cuc3-105 lines showed a partial suppression of the serration compared with the single ... UFOoexp lines

Hasson A, Plessis A, Blein T, Adroher B, Grigg S, Tsiantis M, Boudaoud A, Damerval C, Laufs P - Evolution and diverse roles of the CUP-SHAPED COTYLEDON genes in Arabidopsis leaf development

• Genetic Interaction

Inactivating MIR164A in the serrated mutant/transgenic lines suggested that ... CBP20 act via a pathway requiring MIR164A

Hasson A, Plessis A, Blein T, Adroher B, Grigg S, Tsiantis M, Boudaoud A, Damerval C, Laufs P - Evolution and diverse roles of the CUP-SHAPED COTYLEDON genes in Arabidopsis leaf development

• Genetic Interaction

stip-D cuc3-105 ... showed a partial suppression of the serration compared with the single stip-D ... lines

Hasson A, Plessis A, Blein T, Adroher B, Grigg S, Tsiantis M, Boudaoud A, Damerval C, Laufs P - Evolution and diverse roles of the CUP-SHAPED COTYLEDON genes in Arabidopsis leaf development

• Genetic Interaction

synergistic phenotype of ven3 ven6 double mutants suggests a functional relationship between VEN3 and VEN6

Mollá-Morales A, Sarmiento-Mañús R, Robles P, Quesada V, Pérez-Pérez JM, González-Bayón R, Hannah MA, Willmitzer L, Ponce MR, Micol JL - Analysis of ven3 and ven6 reticulate mutants reveals the importance of arginine biosynthesis in Arabidopsis leaf development

• Genetic Interaction

leaves of the ven3-1/ven3-1 ven6-1/ven6-1 double mutant were smaller

Mollá-Morales A, Sarmiento-Mañús R, Robles P, Quesada V, Pérez-Pérez JM, González-Bayón R, Hannah MA, Willmitzer L, Ponce MR, Micol JL - Analysis of ven3 and ven6 reticulate mutants reveals the importance of arginine biosynthesis in Arabidopsis leaf development

• Genetic Interaction

ven3-2/ven3-2 ven6-1/ven6-1 was more severe; this double mutant had very small leaves

Mollá-Morales A, Sarmiento-Mañús R, Robles P, Quesada V, Pérez-Pérez JM, González-Bayón R, Hannah MA, Willmitzer L, Ponce MR, Micol JL - Analysis of ven3 and ven6 reticulate mutants reveals the importance of arginine biosynthesis in Arabidopsis leaf development

• Genetic Interaction

leaves of the ven3-1/ven3-1 ven6-1/ven6-1 double mutant were ... paler green

Mollá-Morales A, Sarmiento-Mañús R, Robles P, Quesada V, Pérez-Pérez JM, González-Bayón R, Hannah MA, Willmitzer L, Ponce MR, Micol JL - Analysis of ven3 and ven6 reticulate mutants reveals the importance of arginine biosynthesis in Arabidopsis leaf development

• Genetic Interaction

leaves of the ven3-1/ven3-1 ven6-1/ven6-1 double mutant ... showed prominent marginal indentations

Mollá-Morales A, Sarmiento-Mañús R, Robles P, Quesada V, Pérez-Pérez JM, González-Bayón R, Hannah MA, Willmitzer L, Ponce MR, Micol JL - Analysis of ven3 and ven6 reticulate mutants reveals the importance of arginine biosynthesis in Arabidopsis leaf development

• Genetic Interaction

The hfr1-101 allele led to a further reduction in phyB-9 biomass at 28°C and not 21°C, supporting our observations that HFR1 is important for restraining elongation growth at warm temperatures

Foreman J, Johansson H, Hornitschek P, Josse EM, Fankhauser C, Halliday KJ - Light receptor action is critical for maintaining plant biomass at warm ambient temperatures

• Genetic Interaction

In accordance with HFR1 negatively regulating PIF4, the pif4-101 null allele partially restored biomass response to phyB-9hfr1-101 at both temperatures

Foreman J, Johansson H, Hornitschek P, Josse EM, Fankhauser C, Halliday KJ - Light receptor action is critical for maintaining plant biomass at warm ambient temperatures

• Genetic Interaction

Importantly, transformation of nhx5 nhx6 with either C terminus–tagged NHX5-YFP (for yellow fluorescent protein) or NHX6-GFP (for green fluorescent protein) rescued the nhx5 nhx6 phenotype because both NHX5-YFP nhx5 nhx6 and NHX6-GFP nhx5 nhx6 resembled the wild type/single knockouts

Bassil E, Ohto MA, Esumi T, Tajima H, Zhu Z, Cagnac O, Belmonte M, Peleg Z, Yamaguchi T, Blumwald E - The Arabidopsis intracellular Na+/H+ antiporters NHX5 and NHX6 are endosome associated and necessary for plant growth and development

• Genetic Interaction

Importantly, transformation of nhx5 nhx6 with either C terminus–tagged NHX5-YFP (for yellow fluorescent protein) or NHX6-GFP (for green fluorescent protein) rescued the nhx5 nhx6 phenotype because both NHX5-YFP nhx5 nhx6 and NHX6-GFP nhx5 nhx6 resembled the wild type/single knockouts

Bassil E, Ohto MA, Esumi T, Tajima H, Zhu Z, Cagnac O, Belmonte M, Peleg Z, Yamaguchi T, Blumwald E - The Arabidopsis intracellular Na+/H+ antiporters NHX5 and NHX6 are endosome associated and necessary for plant growth and development

• Genetic Interaction

The bpc1-1 bpc2 bpc3-1 plants did not exhibit the silique abortion or curled leaves seen in bpc1-1 bpc2 plants, indicating that the addition of the bpc3-1 allele to bpc1-1 bpc2 suppressed these defects (Figures 3a and S4b). The addition of the bpc3-1 allele to bpc1-1 bpc2 also restored plant height and rosette diameter to near wild-type levels

Monfared MM, Simon MK, Meister RJ, Roig-Villanova I, Kooiker M, Colombo L, Fletcher JC, Gasser CS - Overlapping and antagonistic activities of BASIC PENTACYSTEINE genes affect a range of developmental processes in Arabidopsis

• Genetic Interaction

The loss of BPC3 activity produced by the introduction of either bpc3-1 or bpc3-2 into the bpc1-1 bpc2 bpc4 bpc6 background suppressed both the dwarfism and short primary inflorescence phenotypes

Monfared MM, Simon MK, Meister RJ, Roig-Villanova I, Kooiker M, Colombo L, Fletcher JC, Gasser CS - Overlapping and antagonistic activities of BASIC PENTACYSTEINE genes affect a range of developmental processes in Arabidopsis

• Genetic Interaction

bpc3-1 or bpc3-2 into the bpc1-1 bpc2 bpc4 bpc6 background suppressed ... The rosette leaves of the pentuple mutants were intermediate in length and width between those of wild type and the quadruple mutants, and were more normal in shape than those of the quadruple mutants, with curling occurring only at the edges

Monfared MM, Simon MK, Meister RJ, Roig-Villanova I, Kooiker M, Colombo L, Fletcher JC, Gasser CS - Overlapping and antagonistic activities of BASIC PENTACYSTEINE genes affect a range of developmental processes in Arabidopsis

• Genetic Interaction

spa1 is epistatic to phyB in the regulation of leaf morphology

Ranjan A, Fiene G, Fackendahl P, Hoecker U - The Arabidopsis repressor of light signaling SPA1 acts in the phloem to regulate seedling de-etiolation, leaf expansion and flowering time

• Genetic Interaction

We then introduced the ant-1 mutation into 35S-OSR1 transgenic plants, and, as expected, the ant-1 mutation dramatically blocked leaf enlargement in 35S-OSR1 plants (Fig. 4b). Because ANT stimulates organ growth by promoting cell proliferation (Mizukami & Fischer, 2000), we reasoned that the slight size increase in 35S-OSR1/ant-1 leaves may be attributable to the effect of OSR1 on cell expansion. To test this hypothesis, we carefully determined palisade cell size and the number of fully expanded fifth leaves in ant-1 and 35S-OSR1/ant-1 plants, and found that the ant-1 mutation indeed completely blocked the effect of 35S-OSR1 on cell proliferation, but not its effect on cell expansion (Fig. 4c,d), confirming that OSR1-mediated cell proliferation, but not cell expansion, occurs through the ANT pathway during organogenesis

Feng G, Qin Z, Yan J, Zhang X, Hu Y - Arabidopsis ORGAN SIZE RELATED1 regulates organ growth and final organ size in orchestration with ARGOS and ARL

• Genetic Interaction

At the seedling stage, formation of ovate-shaped cotyledons and leaves by OFP4 overexpression was suppressed in the knat7 background ... At the rosette stage, suppression of the ... OFP4 overexpression phenotype in knat7, relative to the KNAT7 background, was more pronounced, with both double mutants exhibiting wild-type morphology

Li E, Wang S, Liu Y, Chen JG, Douglas CJ - OVATE FAMILY PROTEIN4 (OFP4) interaction with KNAT7 regulates secondary cell wall formation in Arabidopsis thaliana

• Genetic Interaction

formation of ovate-shaped cotyledons and leaves ... At the rosette stage, suppression of the OFP1 ... overexpression phenotype in knat7, relative to the KNAT7 background, was more pronounced, with both double mutants exhibiting wild-type morphology

Li E, Wang S, Liu Y, Chen JG, Douglas CJ - OVATE FAMILY PROTEIN4 (OFP4) interaction with KNAT7 regulates secondary cell wall formation in Arabidopsis thaliana

• Genetic Interaction

The leaves show blade shape defects in the order WT >tcp14>tcp15>tcp14 tcp15

Kieffer M, Master V, Waites R, Davies B - TCP14 and TCP15 affect internode length and leaf shape in Arabidopsis

• Genetic Interaction

The tcp14-4 tcp15-3 double mutant showed a further significant reduction in inflorescence height

Kieffer M, Master V, Waites R, Davies B - TCP14 and TCP15 affect internode length and leaf shape in Arabidopsis

• Genetic Interaction

35S:FYF functions downstream of ETR1 ... is epistatic to ... etr1 ... in the ethylene-insensitive response

Chen MK, Hsu WH, Lee PF, Thiruvengadam M, Chen HI, Yang CH. - The MADS box gene, FOREVER YOUNG FLOWER, acts as a repressor controlling floral organ senescence and abscission in Arabidopsis

• Genetic Interaction

35S:FYF functions downstream of ... EIN2 ... is epistatic to ... ein2 ... in the ethylene-insensitive response

Chen MK, Hsu WH, Lee PF, Thiruvengadam M, Chen HI, Yang CH. - The MADS box gene, FOREVER YOUNG FLOWER, acts as a repressor controlling floral organ senescence and abscission in Arabidopsis

• Genetic Interaction

Our data show that ALG10 adds the terminal glucose residue to the lipid-linked oligosaccharide. Based on these results we hypothesized that in the absence of the terminal glucose the activity of GCSI, which removes this residue, is not required for normal processing of N-glycans. As a consequence ALG10-deficient mutants might be able to rescue the defects observed for the knf-14 GCSI loss-of-function mutant (Gillmor et al., 2002) and for the weak knf-101 allele (Furumizu and Komeda, 2008). To test our hypothesis we crossed alg10-1 to knf-14 as well as knf-101 and screened by PCR and sequence analysis for putative double mutants. We could identify several lines, which were knockout for alg10-1 and homozygous for the point mutations of knf-14 or knf-101. Remarkably, the alg10-1 knf-14 double mutant was viable and seedlings were indistinguishable from alg10-1 and wild-type plants when grown on MS medium

Farid A, Pabst M, Schoberer J, Altmann F, Glössl J, Strasser R. - Arabidopsis thaliana alpha1,2-glucosyltransferase (ALG10) is required for efficient N-glycosylation and leaf growth

• Genetic Interaction

These results thus suggested that the atm-4 mutation has additive effects on the mdo1-1 shoot and root phenotypes

Hashimura Y, Ueguchi C - The Arabidopsis MERISTEM DISORGANIZATION 1 gene is required for the maintenance of stem cells through the reduction of DNA damage

• Genetic Interaction

rug2-1 sca3-1 double mutants ... synergistic ... narrow ... leaves

Quesada V, Sarmiento-Mañús R, González-Bayón R, Hricová A, Pérez-Marcos R, Graciá-Martínez E, Medina-Ruiz L, Leyva-Díaz E, Ponce MR, Micol JL - Arabidopsis RUGOSA2 encodes an mTERF family member required for mitochondrion, chloroplast and leaf development

• Genetic Interaction

rug2-1 sca3-1 double mutants ... synergistic ... plant size was substantially reduced compared with that of the parental mutants

Quesada V, Sarmiento-Mañús R, González-Bayón R, Hricová A, Pérez-Marcos R, Graciá-Martínez E, Medina-Ruiz L, Leyva-Díaz E, Ponce MR, Micol JL - Arabidopsis RUGOSA2 encodes an mTERF family member required for mitochondrion, chloroplast and leaf development

• Genetic Interaction

rug2-1 sca3-1 double mutants to be synergistic because they displayed very small ... leaves

Quesada V, Sarmiento-Mañús R, González-Bayón R, Hricová A, Pérez-Marcos R, Graciá-Martínez E, Medina-Ruiz L, Leyva-Díaz E, Ponce MR, Micol JL - Arabidopsis RUGOSA2 encodes an mTERF family member required for mitochondrion, chloroplast and leaf development

• Genetic Interaction

rug2-1 sca3-1 double mutants ... synergistic ... pale green leaves

Quesada V, Sarmiento-Mañús R, González-Bayón R, Hricová A, Pérez-Marcos R, Graciá-Martínez E, Medina-Ruiz L, Leyva-Díaz E, Ponce MR, Micol JL - Arabidopsis RUGOSA2 encodes an mTERF family member required for mitochondrion, chloroplast and leaf development

• Genetic Interaction

To test this possibility we generated an as1 co double mutant using the possible co null mutant (co-101; Takada and Goto, 2003), which we found has a T-DNA insertion in the same position to the null co-10 allele (data not shown) (Laubinger et al., 2006). When we analyzed flowering phenotype under five different photoperiods (from SD to LD), we found that the co as1 double mutant always demonstrated a later flowering than the co mutant (Figure 4a). When the co as1 double mutant was grown under the 12L/12D conditions with exogenous GA3 application, the flowering phenotype of the double mutant was indistinguishable with that of the co mutant (Figure 4b). This result shows that the later flowering phenotype of the co as1 mutant caused by the addition of as1 mutation was rescued by the treatment of GA application and that the GA-independent as1 flowering phenotype did not exist when the co is mutated. This result implies that the GA-independent AS1 flowering function seems to be dependent on the CO function

Song YH, Lee I, Lee SY, Imaizumi T, Hong JC - CONSTANS and ASYMMETRIC LEAVES 1 complex is involved in the induction of FLOWERING LOCUS T in photoperiodic flowering in Arabidopsis.

• Genetic Interaction

leaves ... as2-1 rev-1 ... were smaller than ... those of the corresponding single mutants

Wang W, Xu B, Wang H, Li J, Huang H, Xu L - YUCCA genes are expressed in response to leaf adaxial-abaxial juxtaposition and are required for leaf margin development

• Genetic Interaction

leaves of ... kan1-11 kan2-5 were smaller than ... those of the corresponding single mutants

Wang W, Xu B, Wang H, Li J, Huang H, Xu L - YUCCA genes are expressed in response to leaf adaxial-abaxial juxtaposition and are required for leaf margin development

• Genetic Interaction

prs-2 wox1-101 double mutant ... These results indicate that PRS and WOX1 are redundantly required for cell proliferation in the blade outgrowth of leaves and petals

Nakata M, Matsumoto N, Tsugeki R, Rikirsch E, Laux T, Okada K - Roles of the middle domain-specific WUSCHEL-RELATED HOMEOBOX genes in early development of leaves in Arabidopsis

• Genetic Interaction

To determine whether as1 can also enhance the leaf phenotype of the jaw-D mutant, we constructed the as1-1 jaw-D double mutant. The leaf morphology of as1-1 jaw-D is similar to that of as2-1 jaw-D (Figure 2k,l), except for the shorter petiole in as1-1 jaw-D, suggesting that the enhancement of the phenotype in the double mutant plants is mediated by the AS1– AS2 complex

Li Z, Li B, Shen WH, Huang H, Dong A - TCP transcription factors interact with AS2 in the repression of class-I KNOX genes in Arabidopsis thaliana

• Genetic Interaction

Interestingly, these phenotypes were dramatically enhanced in the as2- 1 jaw-D double mutant, with an apparently increased number of leaflets on the leaves (Figure S3). In addition, as2-1 leaves usually carried lobes in the proximal part, whereas in as2-1 jaw-D double mutants, lobes appeared in both the proximal and distal regions

Li Z, Li B, Shen WH, Huang H, Dong A - TCP transcription factors interact with AS2 in the repression of class-I KNOX genes in Arabidopsis thaliana

• Genetic Interaction

Addition of the ail7-1 allele into the stm-1 ail6-2 ... partially suppresses the severity of these phenotypes with a higher percentage of plants producing leaves ... Some stm-1 ail6-2 ail7-1 triple mutants bolt and make flowers resembling those of stm-1

Mudunkothge JS, Krizek BA - Three Arabidopsis AIL/PLT genes act in combination to regulate shoot apical meristem function

• Genetic Interaction

Addition of the ail7-1 allele into ... stm-1 ant-4 ail6-2 ... partially suppresses the severity of these phenotypes with a higher percentage of plants producing leaves

Mudunkothge JS, Krizek BA - Three Arabidopsis AIL/PLT genes act in combination to regulate shoot apical meristem function

• Genetic Interaction

35S:STU was able to partially rescue the reduced stature of ga1-3

Lee LY, Hou X, Fang L, Fan S, Kumar PP, Yu H - STUNTED mediates the control of cell proliferation by GA in Arabidopsis

• Genetic Interaction

NULL

Lee LY, Hou X, Fang L, Fan S, Kumar PP, Yu H - STUNTED mediates the control of cell proliferation by GA in Arabidopsis

• Genetic Interaction

loss of SIM function in sim-1 significantly suppressed the defects in stu-1

Lee LY, Hou X, Fang L, Fan S, Kumar PP, Yu H - STUNTED mediates the control of cell proliferation by GA in Arabidopsis

• Genetic Interaction

SIM indeed acts downstream of STU in the control of cell division

Lee LY, Hou X, Fang L, Fan S, Kumar PP, Yu H - STUNTED mediates the control of cell proliferation by GA in Arabidopsis

• Genetic Interaction

exi2 ... aba1-1 ... The rosette phenotypes of the six exi aba double mutant combinations studied were all similar: they displayed small and darker-green vegetative leaves as in their exi parental, as well as the wilty phenotype characteristic of their ABA-deficient parental (Figure 6C and data not shown). In addition, rosette size was more reduced in the double mutants than in any of their parentals. We interpreted the phenotype of the exi aba double mutants as additive

Rubio-Díaz S, Pérez-Pérez JM, González-Bayón R, Muñoz-Viana R, Borrega N, Mouille G, Hernández-Romero D, Robles P, Höfte H, Ponce MR, Micol JL - Cell expansion-mediated organ growth is affected by mutations in three EXIGUA genes

• Genetic Interaction

exi5 ... aba2-13 ... The rosette phenotypes of the six exi aba double mutant combinations studied were all similar: they displayed small and darker-green vegetative leaves as in their exi parental, as well as the wilty phenotype characteristic of their ABA-deficient parental (Figure 6C and data not shown). In addition, rosette size was more reduced in the double mutants than in any of their parentals. We interpreted the phenotype of the exi aba double mutants as additive

Rubio-Díaz S, Pérez-Pérez JM, González-Bayón R, Muñoz-Viana R, Borrega N, Mouille G, Hernández-Romero D, Robles P, Höfte H, Ponce MR, Micol JL - Cell expansion-mediated organ growth is affected by mutations in three EXIGUA genes

• Genetic Interaction

exi5 ... aba1-1 ... The rosette phenotypes of the six exi aba double mutant combinations studied were all similar: they displayed small and darker-green vegetative leaves as in their exi parental, as well as the wilty phenotype characteristic of their ABA-deficient parental (Figure 6C and data not shown). In addition, rosette size was more reduced in the double mutants than in any of their parentals. We interpreted the phenotype of the exi aba double mutants as additive

Rubio-Díaz S, Pérez-Pérez JM, González-Bayón R, Muñoz-Viana R, Borrega N, Mouille G, Hernández-Romero D, Robles P, Höfte H, Ponce MR, Micol JL - Cell expansion-mediated organ growth is affected by mutations in three EXIGUA genes

• Genetic Interaction

exi1-1 ... aba2-13 ... The rosette phenotypes of the six exi aba double mutant combinations studied were all similar: they displayed small and darker-green vegetative leaves as in their exi parental, as well as the wilty phenotype characteristic of their ABA-deficient parental (Figure 6C and data not shown). In addition, rosette size was more reduced in the double mutants than in any of their parentals. We interpreted the phenotype of the exi aba double mutants as additive

Rubio-Díaz S, Pérez-Pérez JM, González-Bayón R, Muñoz-Viana R, Borrega N, Mouille G, Hernández-Romero D, Robles P, Höfte H, Ponce MR, Micol JL - Cell expansion-mediated organ growth is affected by mutations in three EXIGUA genes

• Genetic Interaction

exi2 exi5 double mutant ... were dwarf ... we considered the ... mutant phenotype as additive

Rubio-Díaz S, Pérez-Pérez JM, González-Bayón R, Muñoz-Viana R, Borrega N, Mouille G, Hernández-Romero D, Robles P, Höfte H, Ponce MR, Micol JL - Cell expansion-mediated organ growth is affected by mutations in three EXIGUA genes

• Genetic Interaction

exi2 ... aba2-13 ... The rosette phenotypes of the six exi aba double mutant combinations studied were all similar: they displayed small and darker-green vegetative leaves as in their exi parental, as well as the wilty phenotype characteristic of their ABA-deficient parental (Figure 6C and data not shown). In addition, rosette size was more reduced in the double mutants than in any of their parentals. We interpreted the phenotype of the exi aba double mutants as additive

Rubio-Díaz S, Pérez-Pérez JM, González-Bayón R, Muñoz-Viana R, Borrega N, Mouille G, Hernández-Romero D, Robles P, Höfte H, Ponce MR, Micol JL - Cell expansion-mediated organ growth is affected by mutations in three EXIGUA genes

• Genetic Interaction

exi1-1 ... aba1-1 ... The rosette phenotypes of the six exi aba double mutant combinations studied were all similar: they displayed small and darker-green vegetative leaves as in their exi parental, as well as the wilty phenotype characteristic of their ABA-deficient parental (Figure 6C and data not shown). In addition, rosette size was more reduced in the double mutants than in any of their parentals. We interpreted the phenotype of the exi aba double mutants as additive

Rubio-Díaz S, Pérez-Pérez JM, González-Bayón R, Muñoz-Viana R, Borrega N, Mouille G, Hernández-Romero D, Robles P, Höfte H, Ponce MR, Micol JL - Cell expansion-mediated organ growth is affected by mutations in three EXIGUA genes

• Genetic Interaction

exi2 exi5 double mutant ... had ... dark-green leaves ... we considered the ... double mutant phenotype as additive

Rubio-Díaz S, Pérez-Pérez JM, González-Bayón R, Muñoz-Viana R, Borrega N, Mouille G, Hernández-Romero D, Robles P, Höfte H, Ponce MR, Micol JL - Cell expansion-mediated organ growth is affected by mutations in three EXIGUA genes

• Genetic Interaction

Analysis of double mir164a-4/dpa4 mutants confirmed that DPA4 and miR164 act as independent antagonists of leaf serrations. The double mir164a-4/dpa4 mutants displayed enhanced serrations compared with either single mutant, indicating a parallel action of miR164 and DPA4 ... The substantial increase in depth in the most basal serrations and juvenile leaves suggests an at least additive phenotype in the double mir164a-4/dpa4 mutant

Engelhorn J, Reimer JJ, Leuz I, Göbel U, Huettel B, Farrona S, Turck F - Development-related PcG target in the apex 4 controls leaf margin architecture in Arabidopsis thaliana

• Genetic Interaction

The alleles of dpa4 and cuc2-1 are in different genetic backgrounds, which show differences in leaf serration and leaf shape (cuc2-1 in Ler; dpa4 in Col-0). We therefore scored several double-homozygous cuc2-1/dpa4 F3 families for their degree of serration to account for phenotypic alterations caused by the genetic background. None of the cuc2-1/dpa4 plants displayed any serrations, whereas serrations occurred in all single-homozygous dpa4 families. In conclusion, serrations are abolished in cuc2-1/dpa4 double mutants

Engelhorn J, Reimer JJ, Leuz I, Göbel U, Huettel B, Farrona S, Turck F - Development-related PcG target in the apex 4 controls leaf margin architecture in Arabidopsis thaliana

• Genetic Interaction

To test this hypothesis, we crossed the pin2, pin3, pin4, and pin7 mutants, which have no obvious phyllotactic phenotype under normal growth conditions, into the pin1 background ... No double mutant combination showed an increased phenotypic severity compared with pin1, except for pin1pin4. A high proportion of pin1pin4 seedlings had a single cotyledon

Guenot B, Bayer E, Kierzkowski D, Smith RS, Mandel T, Žádníková P, Benková E, Kuhlemeier C - Pin1-independent leaf initiation in Arabidopsis

• Genetic Interaction

the average plastochron of pin1pin4 leaves (5 d; n = 154) was significantly longer than in pin1 (P < 0.05

Guenot B, Bayer E, Kierzkowski D, Smith RS, Mandel T, Žádníková P, Benková E, Kuhlemeier C - Pin1-independent leaf initiation in Arabidopsis

• Genetic Interaction

this ectopic PIN3 expression did not rescue the lack of PIN1 function

Guenot B, Bayer E, Kierzkowski D, Smith RS, Mandel T, Žádníková P, Benková E, Kuhlemeier C - Pin1-independent leaf initiation in Arabidopsis

• Genetic Interaction

Compared with the sub-2 or axr1-3 single mutant, the sub-2 axr1-3 double mutant showed reduced complexity of venation patterning at both temperatures (Figure 4g,h and Table 1). Discontinuous veins were significantly increased and more vascular islands appeared in sub-2 axr1-3 leaves, particularly at 30°C (Figure 4h and Table 1), suggesting that SUB acts synergistically with AXR1 in venation patterning

Lin L, Zhong SH, Cui XF, Li J, He ZH - Characterization of temperature-sensitive mutants reveals a role for receptor-like kinase SCRAMBLED/STRUBBELIG in coordinating cell proliferation and differentiation during Arabidopsis leaf development

• Genetic Interaction

To demonstrate that the observed growth phenotype is caused by the samba-1 and samba-2 mutations, we engineered a rescue construct (pSAMBA:SAMBA) consisting of 1,817 bp of the promoter sequence fused to the SAMBA full-length genomic sequence. Transgenic lines expressing this construction complemented the samba growth phenotype in both mutant lines analyzed (Fig. S3A

Eloy NB, Gonzalez N, Van Leene J, Maleux K, Vanhaeren H, De Milde L, Dhondt S, Vercruysse L, Witters E, Mercier R, Cromer L, Beemster GT, Remaut H, Van Montagu MC, De Jaeger G, Ferreira PC, Inzé D - SAMBA, a plant-specific anaphase-promoting complex/cyclosome regulator is involved in early development and A-type cyclin stabilization

• Genetic Interaction

The ccs52a2-3 mgo1-1 double mutants were indistinguishable from mgo-1 (Figure 9A, C) under our conditions, suggesting that MGO1 may be epistatic to CCS52A2

Liu Y, Ye W, Li B, Zhou X, Cui Y, Running MP, Liu K - CCS52A2/FZR1, a cell cycle regulator, is an essential factor for shoot apical meristem maintenance in Arabidopsis thaliana

• Genetic Interaction

rug2-2 × mda1-2 crosses allowed us to identify additive double mutant phenotypes

Robles P, Micol JL, Quesada V - Arabidopsis MDA1, a nuclear-encoded protein, functions in chloroplast development and abiotic stress responses

• Genetic Interaction

mda1-2 × soldat10 crosses, we identified double mutants with a clearly additive phenotype

Robles P, Micol JL, Quesada V - Arabidopsis MDA1, a nuclear-encoded protein, functions in chloroplast development and abiotic stress responses

• Genetic Interaction

rug2-2 × mda1-1 ... crosses allowed us to identify additive double mutant phenotypes

Robles P, Micol JL, Quesada V - Arabidopsis MDA1, a nuclear-encoded protein, functions in chloroplast development and abiotic stress responses

• Genetic Interaction

As regards the mda1-1 × soldat10 ... crosses, we identified double mutants with a clearly additive phenotype

Robles P, Micol JL, Quesada V - Arabidopsis MDA1, a nuclear-encoded protein, functions in chloroplast development and abiotic stress responses

• Genetic Interaction

we performed a genetic complementation analysis by crossing our BAT1 over-expression line with the DWF4 over-expressing line, which contains high levels of endogenous BRs (Choe et al., 2001; Wang et al., 2001; Nemhauser et al., 2004). The architecture of the aerial parts of parental DWF4 transgenic plants was larger than that of the wild-type, with an increased number of branches and siliques. The crossed F1 plants over-expressing both BAT1 and DWF4 showed wild-type phenotypes, with a reduced height of inflorescence stems compared to the DWF4 transgenic plants (Figure 5c), indicating that BAT1 may modulate the high endogenous BR levels in DWF4 over-expressing plants

Choi S, Cho YH, Kim K, Matsui M, Son SH, Kim SK, Fujioka S, Hwang I - BAT1, a putative acyltransferase, modulates brassinosteroid levels in Arabidopsis

• Genetic Interaction

The epidermis of the spch mutant was composed solely of expanded PCs with no stomatal-lineage cells. The phenotype of spch aba2-2 double mutant is identical to the spch single mutant, without significant size difference for both – one mean PC and the whole cotyledon size as well as the total PC number per one cotyledon (Figures 5a,c and d) and S6a) – indicating that SPCH is epistatic to ABA2

Tanaka Y, Nose T, Jikumaru Y, Kamiya Y - ABA inhibits entry into stomatal-lineage development in Arabidopsis leaves

• Genetic Interaction

the mute aba2-2 double mutant is additive

Tanaka Y, Nose T, Jikumaru Y, Kamiya Y - ABA inhibits entry into stomatal-lineage development in Arabidopsis leaves

• Genetic Interaction

addition of a bsk1 mutation to the bsk3,4,6,7 mutant, resulting in the bsk1,3,4,6,7 pentuple mutant, partially suppressed the bsk3,4,6,7 phenotype

Sreeramulu S, Mostizky Y, Sunitha S, Shani E, Nahum H, Salomon D, Hayun LB, Gruetter C, Rauh D, Ori N, Sessa G - BSKs are partially redundant positive regulators of brassinosteroid signaling in Arabidopsis

• Genetic Interaction

In hdg2 rosette leaf abaxial epidermis, meristemoids occasionally failed to differentiate into stomata (supplementary material Fig. S5D). The phenotype was exaggerated by the additional atml1 mutation, and excessive numbers of SLGCs were seen in the hdg2 atml1 rosette leaf epidermis, implying extended asymmetric cell division state due to delayed differentiation

Peterson KM, Shyu C, Burr CA, Horst RJ, Kanaoka MM, Omae M, Sato Y, Torii KU - Arabidopsis homeodomain-leucine zipper IV proteins promote stomatal development and ectopically induce stomata beyond the epidermis

• Genetic Interaction

loss of the second homologous gene (At1g51340) has a additive effect on the mutant phenotype caused by the loss of At3g08040

Bolle C, Huep G, Kleinbölting N, Haberer G, Mayer K, Leister D, Weisshaar B - GABI-DUPLO: a collection of double mutants to overcome genetic redundancy in Arabidopsis thaliana

• Genetic Interaction

We co-expressed STM with CYCD3;1 (STMoe/CYCD3;1oe) and observed a strongly synergistic phenotype

Scofield S, Dewitte W, Nieuwland J, Murray JA - The Arabidopsis homeobox gene SHOOT MERISTEMLESS has cellular and meristem-organisational roles with differential requirements for cytokinin and CYCD3 activity

• Genetic Interaction

STMoe/CYCD3;1oe ... Leaf outgrowth and differentiation were almost completely inhibited

Scofield S, Dewitte W, Nieuwland J, Murray JA - The Arabidopsis homeobox gene SHOOT MERISTEMLESS has cellular and meristem-organisational roles with differential requirements for cytokinin and CYCD3 activity

• Genetic Interaction

Using plants hemizygous for the STMoe constructs with moderate levels of induced STM activity and equivalent in phenotypic severity to KNAT1oe and KNAT2oe, we found that the effect of STM on leaf morphology, (uneven leaf surface and margins; Figure 3e,f) was completely suppressed by combined CKX1 misexpression

Scofield S, Dewitte W, Nieuwland J, Murray JA - The Arabidopsis homeobox gene SHOOT MERISTEMLESS has cellular and meristem-organisational roles with differential requirements for cytokinin and CYCD3 activity

• Genetic Interaction

The phenotype of hat3-3 athb4-1 athb2-1 and hat3-3 athb4-1 athb2-3 is significantly more severe than that of hat3-3 athb4-1. Remarkably, almost all triple mutants display radialized cotyledons. Moreover, the number of seedlings with fused/single cotyledon(s) is significantly higher in the hat3-3 athb4-1 athb2-1 and hat3-3 athb4-1 athb2-3 populations than in the hat3-3 athb4-1 one

Turchi L, Carabelli M, Ruzza V, Possenti M, Sassi M, Peñalosa A, Sessa G, Salvi S, Forte V, Morelli G, Ruberti I - Arabidopsis HD-Zip II transcription factors control apical embryo development and meristem function

• Genetic Interaction

Loss of PHV ... enhances hat3-3 athb4-1 defects in bilateral symmetry

Turchi L, Carabelli M, Ruzza V, Possenti M, Sassi M, Peñalosa A, Sessa G, Salvi S, Forte V, Morelli G, Ruberti I - Arabidopsis HD-Zip II transcription factors control apical embryo development and meristem function

• Genetic Interaction

We then isolated and characterized hat3-3 athb4-1/+ rev-5 (supplementary material Tables S10, S13). Almost all hat3-3 athb4-1 rev-5 seedlings with two cotyledons as well as those with single cotyledon (Fig. 7I-L; supplementary material Fig. S14) lack an active SAM (hat3-3 athb4-1, 1/224; hat3-3 athb4-1 rev-5, 24/30; P<0.0001). Loss of REV also significantly enhances hat3-3 athb4-1 defects in bilateral symmetry

Turchi L, Carabelli M, Ruzza V, Possenti M, Sassi M, Peñalosa A, Sessa G, Salvi S, Forte V, Morelli G, Ruberti I - Arabidopsis HD-Zip II transcription factors control apical embryo development and meristem function

• Genetic Interaction

We investigated next whether the lack of ATHB2 enhances the SAM phenotype of hat3-3 athb4-1. Most of the hat3-3 athb4-1 athb2-1 and hat3-3 athb4-1 athb2-3 seedlings with two cotyledons or single cotyledon lack an active SAM (363/388 and 258/283, respectively). Among the triple mutants with two cotyledons are also present few seedlings displaying a pin-like structure in the site of presumptive SAM (10/226 and 9/158, respectively; Fig. 5M-R). The SAM phenotype of both triple mutants is dramatically more severe than that observed in hat3-3 athb4-1 (P<0.0001).

Turchi L, Carabelli M, Ruzza V, Possenti M, Sassi M, Peñalosa A, Sessa G, Salvi S, Forte V, Morelli G, Ruberti I - Arabidopsis HD-Zip II transcription factors control apical embryo development and meristem function

• Genetic Interaction

Remarkably, athb2-2 significantly attenuates the hat3-3 athb4-1 cotyledon development phenotype (Fig. 3I,J; supplementary material Fig. S10 and Table S9). However, no significant difference was observed in cotyledon number between hat3-3 athb4-1 and hat3-3 athb4-1 athb2-2

Turchi L, Carabelli M, Ruzza V, Possenti M, Sassi M, Peñalosa A, Sessa G, Salvi S, Forte V, Morelli G, Ruberti I - Arabidopsis HD-Zip II transcription factors control apical embryo development and meristem function

• Genetic Interaction

Several phenotypic classes were determined according to leaf serration, namely wt–L for plants displaying a WT-like phenotype, and LS, MS, SS and HS for lightly, moderately, severely and highly serrated phenotypes respectively ... by comparing the distribution of the plants in the various classes for the two genotypes, we found that AtSnRK1a1 over-expression partially reversed the OE-AtKRP6 phenotype (Figure 6c,d). While the plant population over-expressing AtKRP6WT alone (total n = 343) showed variable severity of the expected developmental alterations with 12.7% classified as wt–L, 44.4% as intermediate phenotype (LS + MS), 21.4% SS and 21.4% HS, the population over-expressing AtKRP6WT together with AtSnRK1a1 displayed a shift towards the WT-like phenotype (21.1% wt–L, 42% LS+MS, 19.8% SS and 17.1% HS) (Figure 6c,d). This shift towards the WT-like phenotype is due to a slight decrease (2–4%) in the proportions of all the other classes

Guérinier T, Millan L, Crozet P, Oury C, Rey F, Valot B, Mathieu C, Vidal J, Hodges M, Thomas M, Glab N - Phosphorylation of p27(KIP1) homologs KRP6 and 7 by SNF1-related protein kinase-1 links plant energy homeostasis and cell proliferation

• Genetic Interaction

The chloroplast division phenotype was rescued when the frs4/cpd25 mutant was transformed with a 35Spro-CPD45 transgene

Gao Y, Liu H, An C, Shi Y, Liu X, Yuan W, Zhang B, Yang J, Yu C, Gao H - Arabidopsis FRS4/CPD25 and FHY3/CPD45 work cooperatively to promote the expression of the chloroplast division gene ARC5 and chloroplast division

• Genetic Interaction

transformation of the fhy3/cpd45 mutant with a 35Spro-CPD25 transgene resulted in a more severe mutant phenotype, with an average of five chloroplasts per cell ... Of the 21 T1 transgenic plants analyzed, 20 have a more severe chloroplast division defect than the fhy3/cpd45 mutant

Gao Y, Liu H, An C, Shi Y, Liu X, Yuan W, Zhang B, Yang J, Yu C, Gao H - Arabidopsis FRS4/CPD25 and FHY3/CPD45 work cooperatively to promote the expression of the chloroplast division gene ARC5 and chloroplast division

• Genetic Interaction

Constitutive overexpression of GFP-ARC5 in the independently transformed frs4/cpd25 mutant also rescued the chloroplast division phenotype

Gao Y, Liu H, An C, Shi Y, Liu X, Yuan W, Zhang B, Yang J, Yu C, Gao H - Arabidopsis FRS4/CPD25 and FHY3/CPD45 work cooperatively to promote the expression of the chloroplast division gene ARC5 and chloroplast division

• Genetic Interaction

To investigate whether AtSAP5 expression can affect AtMBP-1 accumulation in vivo, transgenic plants harboring both 35S::AtSAP5 and 35S::AtMBP-1-YFP transgenes were generated by retransformation and the effect of constitutive co-expression AtSAP5/AtMBP-1 on plant development and AtMBP-1–YFP degradation was assayed. As demonstrated by the example shown in Figure 7(a), growth and development of five individual transgenic plants that over-express AtSAP5 along with AtMBP-1 was similar to that of WT plants, indicating that the developmental defects associated with AtMBP-1 over-expression can be rescued by co-expression of AtSAP5

Kang M, Abdelmageed H, Lee S, Reichert A, Mysore KS, Allen RD - AtMBP-1, an alternative translation product of LOS2, affects abscisic acid responses and is modulated by the E3 ubiquitin ligase AtSAP5

• Genetic Interaction

stip-1 00-11 double mutants ... The surviving few have leaves that resemble the 00-11 single mutants but suffer more severe developmental delays than 00-11 ( Fig. 1R, compared to M). The additive nature of the double mutant phenotypes suggests that STIP and 00-11 likely operate in converging pathways in regulating early seedling development

Skylar A, Matsuwaka S, Wu X - ELONGATA3 is required for shoot meristem cell cycle progression in Arabidopsis thaliana seedlings

• Genetic Interaction

we carried out an EMS mutagenesis in stip-D background and identified a mutant line 00-11 as a second-site suppressor of the stip-D leaf phenotype

Skylar A, Matsuwaka S, Wu X - ELONGATA3 is required for shoot meristem cell cycle progression in Arabidopsis thaliana seedlings

• Genetic Interaction

we generated 00-11 clv3-2 double mutants and again observed two classes of phenotypes. Some of the 00-11 clv3-2 appear to be identical to the small class of 00-11 seedlings, which enter growth arrest following germination. The remaining double mutant seedlings resemble the large class of 00-11 during early stages of vegetative development: elongated cotyledons and petioles, as well as extremely slow leaf growth. However, as these seedlings further develop, they evolve into a phenotype that is the combination of clv3-2 and the large 00-11 phenotypes, with enlarged shoot meristems and elongated leaves. This additive phenotype in the double mutants led us to the conclusion that 00-11 carries a mutation in a gene that acts largely independently of the CLV3/WUS pathway

Skylar A, Matsuwaka S, Wu X - ELONGATA3 is required for shoot meristem cell cycle progression in Arabidopsis thaliana seedlings

• Genetic Interaction

the double mutants abcg9–1 abcg14–1 (Figure 3j,n and Figure S1d) and abcg9–2 abcg14–1 (Figure 3k,n and Figure S1d) displayed a stronger phenotype (27 and 59% smaller than the wild-type, respectively) than the single mutants, suggesting an additive effect of these mutations

Le Hir R, Sorin C, Chakraborti D, Moritz T, Schaller H, Tellier F, Robert S, Morin H, Bako L, Bellini C - ABCG9, ABCG11 and ABCG14 ABC transporters are required for vascular development in Arabidopsis

• Genetic Interaction

another thf1 suppressor line that we identified from the EMS-mutagenized seeds ... We cloned the mutated gene, named sot6, from 80-1 using a map-based cloning strategy. The suppressor gene, sot6, turned out to be prpl11 (Figure 7b), which encodes the plastid ribosomal large subunit 11

Wu W, Zhu Y, Ma Z, Sun Y, Quan Q, Li P, Hu P, Shi T, Lo C, Chu IK, Huang J - Proteomic evidence for genetic epistasis: ClpR4 mutations switch leaf variegation to virescence in Arabidopsis

• Genetic Interaction

neither clpC1 thf1 nor clpC2 thf1 produced variegated leaves (Figure 4b). Thus, reducing the levels of the Clp complex can suppress leaf variegation of both var2 and thf1

Wu W, Zhu Y, Ma Z, Sun Y, Quan Q, Li P, Hu P, Shi T, Lo C, Chu IK, Huang J - Proteomic evidence for genetic epistasis: ClpR4 mutations switch leaf variegation to virescence in Arabidopsis

• Genetic Interaction

heterozygosity at the ClpR4 locus could also rescue var2 leaf variegation to a great degree (Figure 4a), indicating that suppression of leaf variegation by clpR4-3 is dose dependent

Wu W, Zhu Y, Ma Z, Sun Y, Quan Q, Li P, Hu P, Shi T, Lo C, Chu IK, Huang J - Proteomic evidence for genetic epistasis: ClpR4 mutations switch leaf variegation to virescence in Arabidopsis

• Genetic Interaction

To elucidate the molecular mechanisms underlying thf1-mediated leaf variegation, we created an ethyl methanesulfonate (EMS) mutagenized population in the thf1 genetic background. Eight thf1 suppressor lines without leaf variegation were isolated from 8000 independent M2 lines. 47-2, one of the suppressor lines, was selected for further analysis

Wu W, Zhu Y, Ma Z, Sun Y, Quan Q, Li P, Hu P, Shi T, Lo C, Chu IK, Huang J - Proteomic evidence for genetic epistasis: ClpR4 mutations switch leaf variegation to virescence in Arabidopsis

• Genetic Interaction

prpl11-2 can suppress the var2 leaf variegation phenotype

Wu W, Zhu Y, Ma Z, Sun Y, Quan Q, Li P, Hu P, Shi T, Lo C, Chu IK, Huang J - Proteomic evidence for genetic epistasis: ClpR4 mutations switch leaf variegation to virescence in Arabidopsis

• Genetic Interaction

neither clpC1 thf1 nor clpC2 thf1 produced variegated leaves (Figure 4b). Thus, reducing the levels of the Clp complex can suppress leaf variegation of both var2 and thf1

Wu W, Zhu Y, Ma Z, Sun Y, Quan Q, Li P, Hu P, Shi T, Lo C, Chu IK, Huang J - Proteomic evidence for genetic epistasis: ClpR4 mutations switch leaf variegation to virescence in Arabidopsis

• Genetic Interaction

clpR4 partially rescues the hypersensitivity of thf1 to high light

Wu W, Zhu Y, Ma Z, Sun Y, Quan Q, Li P, Hu P, Shi T, Lo C, Chu IK, Huang J - Proteomic evidence for genetic epistasis: ClpR4 mutations switch leaf variegation to virescence in Arabidopsis

• Genetic Interaction

The bri1-5 hat1 hat3 mutant displayed a significantly enhanced dwarf phenotype, compared with bri1-5

Zhang D, Ye H, Guo H, Johnson A, Zhang M, Lin H, Yin Y - Transcription factor HAT1 is phosphorylated by BIN2 kinase and mediates brassinosteroid repressed gene expression in Arabidopsis

• Genetic Interaction

the ETR defect was strongly enhanced in the pgr1 pgr6 double mutant, which carries an additional point mutation in the Rieske subunit of the Cyt b6f complex, making it hypersensitive to lumenal acidification under HL intensity in the pgr1 single mutant (Munekage et al., 2001; Jahns et al., 2002). The pgr1 pgr6 mutant showed a drastic reduction of ETR even at moderate light intensity, suggesting that the activity of the Cyt b6f complex is disturbed, even in the absence of high ∆pH (Figure S2

Martinis J, Glauser G, Valimareanu S, Stettler M, Zeeman SC, Yamamoto H, Shikanai T, Kessler F - ABC1K1/PGR6 kinase: a regulatory link between photosynthetic activity and chloroplast metabolism

• Genetic Interaction

the test of responses to nitric oxide in the double mutant nes1-2 ein2 ... showed that ... ein2 ... epistatic to nes1-2, in terms of visual inspection of cotyledon colour

Du J, Li M, Kong D, Wang L, Lv Q, Wang J, Bao F, Gong Q, Xia J, He Y - Nitric oxide induces cotyledon senescence involving co-operation of the NES1/MAD1 and EIN2-associated ORE1 signalling pathways in Arabidopsis

• Genetic Interaction

the test of responses to nitric oxide in the double mutant ... nes1-2 ore1 showed that ... ore1 ... epistatic to nes1-2, in terms of visual inspection of cotyledon colour

Du J, Li M, Kong D, Wang L, Lv Q, Wang J, Bao F, Gong Q, Xia J, He Y - Nitric oxide induces cotyledon senescence involving co-operation of the NES1/MAD1 and EIN2-associated ORE1 signalling pathways in Arabidopsis

• Genetic Interaction

Taken together, the strong pleiotropic brm1 phenotype is fully penetrant in an3 brm1 leaves, although the effect of an3 mutation is not entirely absent. Given their molecular functions and protein complex formation, this suggests that AN3 works together with BRM to perform at least part of its function during leaf development

Vercruyssen L, Verkest A, Gonzalez N, Heyndrickx KS, Eeckhout D, Han SK, Jégu T, Archacki R, Van Leene J, Andriankaja M, De Bodt S, Abeel T, Coppens F, Dhondt S, De Milde L, Vermeersch M, Maleux K, Gevaert K, Jerzmanowski A, Benhamed M, Wagner D, Vandepoele K, De Jaeger G, Inzé D. - ANGUSTIFOLIA3 binds to SWI/SNF chromatin remodeling complexes to regulate transcription during Arabidopsis leaf development

• Genetic Interaction

rpl36aa enhanced the phenotype of the as2-1 mutant

Casanova-Sáez R, Candela H, Micol JL - Combined haploinsufficiency and purifying selection drive retention of RPL36a paralogs in Arabidopsis

• Genetic Interaction

api2 ... enhanced the phenotype of the as2-1 mutant

Casanova-Sáez R, Candela H, Micol JL - Combined haploinsufficiency and purifying selection drive retention of RPL36a paralogs in Arabidopsis

• Genetic Interaction

high levels of GIF1 enhanced the effects caused by rGRF3 alone ... delay in senescence

Debernardi JM, Mecchia MA, Vercruyssen L, Smaczniak C, Kaufmann K, Inze D, Rodriguez RE, Palatnik JF - Post-transcriptional control of GRF transcription factors by microRNA miR396 and GIF co-activator affects leaf size and longevity

• Genetic Interaction

rGRF3x35S:GIF1 leaves senesced 14 days after detaching, showing again the capacity of GIF1 to stimulate the effects of GRF3

Debernardi JM, Mecchia MA, Vercruyssen L, Smaczniak C, Kaufmann K, Inze D, Rodriguez RE, Palatnik JF - Post-transcriptional control of GRF transcription factors by microRNA miR396 and GIF co-activator affects leaf size and longevity

• Genetic Interaction

Co-overexpression of GRF5 and GIF1 also caused an additional increase in leaf size compared with the single overexpressing lines

Debernardi JM, Mecchia MA, Vercruyssen L, Smaczniak C, Kaufmann K, Inze D, Rodriguez RE, Palatnik JF - Post-transcriptional control of GRF transcription factors by microRNA miR396 and GIF co-activator affects leaf size and longevity

• Genetic Interaction

the leaf size phenotype, being two times larger than the leaves of the single mutants, but still smaller than wild-type ... when GRF5 was overexpressed in the an3-4 mutant

Debernardi JM, Mecchia MA, Vercruyssen L, Smaczniak C, Kaufmann K, Inze D, Rodriguez RE, Palatnik JF - Post-transcriptional control of GRF transcription factors by microRNA miR396 and GIF co-activator affects leaf size and longevity

• Genetic Interaction

co-expression of 35S:GIF1 ... enhanced the activity of GRF3 and additional increase the number of cells in leaves harboring a rGRF3 transgene

Debernardi JM, Mecchia MA, Vercruyssen L, Smaczniak C, Kaufmann K, Inze D, Rodriguez RE, Palatnik JF - Post-transcriptional control of GRF transcription factors by microRNA miR396 and GIF co-activator affects leaf size and longevity

• Genetic Interaction

dark-induced leaf senescence and whole plants, rGRF3 delayed the senescence of an3-1 leaves (Figure 5d, e; see Figure S3b for data with primary transgenic plants). Interestingly, while rGRF3 could not fully recover the organ size of an3-1; rGRF3/an3-1 leaves have a delayed senescence with respect to the wild-type. That the smaller leaves of rGRF3/an3-1 plants senescence later than wild-type suggested that the delay in senescence is not the simple secondary consequence of the increase in leaf size by rGRF3

Debernardi JM, Mecchia MA, Vercruyssen L, Smaczniak C, Kaufmann K, Inze D, Rodriguez RE, Palatnik JF - Post-transcriptional control of GRF transcription factors by microRNA miR396 and GIF co-activator affects leaf size and longevity

• Genetic Interaction

To further study the interaction between GIF1 and GRF3 we analyzed the effect of the expression of rGRF3 in plants deficient in GIF1. The an3-1 mutant (S96 ecotype), lacks GIF1 activity and therefore has smaller leaves (Horiguchi et al., 2005) (Figure 3e). We introduced a rGRF3 transgene in an3-1 and observed a partial complementation of the leaf size phenotype, being two times larger than the leaves of the single mutants, but still smaller than wild-type

Debernardi JM, Mecchia MA, Vercruyssen L, Smaczniak C, Kaufmann K, Inze D, Rodriguez RE, Palatnik JF - Post-transcriptional control of GRF transcription factors by microRNA miR396 and GIF co-activator affects leaf size and longevity

• Genetic Interaction

psi2-1 psi3-1 plants showed an exaggerated dwarf phenotype as compared to the single mutants indicating interaction between PSI2 and PSI3

Stührwohldt N, Hartmann J, Dahlke RI, Oecking C, Sauter M - The PSI family of nuclear proteins is required for growth in arabidopsis

• Genetic Interaction

To examine whether starch accumulation is sufficient, we crossed im with starch excess1 (sex1), a well-characterized starch accumulation mutant that, interestingly, also displays a late-flowering phenotype (Matsoukas et al., 2013); we used null alleles of both im (spotty allele) and sex1 (sex1-1; Yu et al., 2001) for this cross. SEX1 is a starch-related α-glucan/water dikinase that controls the accessibility of degradative enzymes to the starch granule, and starch accumulates in sex1 mutants because it lacks this accessibility (Yu et al., 2001; Yano et al., 2005). Surprisingly, we found that imsex1-1 double mutants recapitulate the phenotype of imgi2 (i.e. they are late flowering [approximately 10 weeks to achieve the floral transition] and produce variegated leaves early in development but all-green leaves later in development; Fig. 11). imsex1-1 and sex1-1 plants also have enhanced rates of carbon assimilation compared with the wild type, similar to that observed for gi2 and imgi2 (Fig. 10C). Considered together, these data indicate, first, that sex1-mediated signaling is able to rescue im variegation in a development-specific manner, and second, that sex1 is epistatic to im with respect to flowering time, photosynthetic carbon assimilation, and chloroplast biogenesis, commencing late in plant development. This suggests that imsex1-1 and imgi2 resemble one another with respect to a number of traits

Putarjunan A, Rodermel S - gigantea suppresses immutans variegation by interactions with cytokinin and gibberellin signaling pathways

• Genetic Interaction

we crossed imgi2 with spy4 (a strong allele of spy; Jacobsen et al., 1996) and identified triple mutants in the segregating F2 population. Consistent with our model, imgi2spy4 mutants were variegated throughout their development (Fig. 6A), and they flowered after about 6 weeks, similar to wild-type and im plants

Putarjunan A, Rodermel S - gigantea suppresses immutans variegation by interactions with cytokinin and gibberellin signaling pathways

• Genetic Interaction

we conclude that gi2 is epistatic to im, or partially so, with respect to flowering time, leaf morphology, and pigment contents

Putarjunan A, Rodermel S - gigantea suppresses immutans variegation by interactions with cytokinin and gibberellin signaling pathways

• Genetic Interaction

Whereas imgi2 is variegated during early plant development, perhaps the most striking phenotype of imgi2 is a suppression of variegation that occurs during late development, commencing approximately 9 weeks after germination. After this time, newly emerging leaves are all green. This suggests that gi2 is able to suppress im variegation in a development-dependent manner

Putarjunan A, Rodermel S - gigantea suppresses immutans variegation by interactions with cytokinin and gibberellin signaling pathways

• Genetic Interaction

a single copy of 35S::MIM156 was totally epistatic to gct ... with regard to abaxial trichome production, it was unable to completely suppress their effect on leaf serrations and the leaf length-to-width ratio

Gillmor CS, Silva-Ortega CO, Willmann MR, Buendía-Monreal M, Poethig RS - The Arabidopsis Mediator CDK8 module genes CCT (MED12) and GCT (MED13) are global regulators of developmental phase transitions

• Genetic Interaction

in ... cct ... ga1-3 – a mutation that blocks GA biosynthesis – further delayed abaxial trichome production

Gillmor CS, Silva-Ortega CO, Willmann MR, Buendía-Monreal M, Poethig RS - The Arabidopsis Mediator CDK8 module genes CCT (MED12) and GCT (MED13) are global regulators of developmental phase transitions

• Genetic Interaction

in gct ... ga1-3 – a mutation that blocks GA biosynthesis – further delayed abaxial trichome production

Gillmor CS, Silva-Ortega CO, Willmann MR, Buendía-Monreal M, Poethig RS - The Arabidopsis Mediator CDK8 module genes CCT (MED12) and GCT (MED13) are global regulators of developmental phase transitions

• Genetic Interaction

a single copy of 35S::MIM156 was totally epistatic to ... cct with regard to abaxial trichome production, it was unable to completely suppress their effect on leaf serrations and the leaf length-to-width ratio

Gillmor CS, Silva-Ortega CO, Willmann MR, Buendía-Monreal M, Poethig RS - The Arabidopsis Mediator CDK8 module genes CCT (MED12) and GCT (MED13) are global regulators of developmental phase transitions

• Genetic Interaction

We considered the phenotype of the mterf9 mda1-1 individuals to be synergistic

Robles P, Micol JL, Quesada V - Mutations in the plant-conserved MTERF9 alter chloroplast gene expression, development and tolerance to abiotic stress in Arabidopsis thaliana

• Genetic Interaction

we considered the phenotype of the ... mda1-1 rps5 double mutants to be synergistic (seedling growth was arrested early in development and individuals exhibited pale green expanded cotyledons and a first pair of tiny leaves

Robles P, Micol JL, Quesada V - Mutations in the plant-conserved MTERF9 alter chloroplast gene expression, development and tolerance to abiotic stress in Arabidopsis thaliana

• Genetic Interaction

mterf9 rps5 double mutants as additive: they displayed the phenotypic traits of parental individuals

Robles P, Micol JL, Quesada V - Mutations in the plant-conserved MTERF9 alter chloroplast gene expression, development and tolerance to abiotic stress in Arabidopsis thaliana

• Genetic Interaction

interpreted the phenotypes of ... mterf9 rpl31 ... double mutants as additive: they displayed the phenotypic traits of parental individuals

Robles P, Micol JL, Quesada V - Mutations in the plant-conserved MTERF9 alter chloroplast gene expression, development and tolerance to abiotic stress in Arabidopsis thaliana

• Genetic Interaction

The phenotypes of the ... mterf9 soldat10 double mutants were considered additive because they exhibited a combination of the parental phenotypes

Robles P, Micol JL, Quesada V - Mutations in the plant-conserved MTERF9 alter chloroplast gene expression, development and tolerance to abiotic stress in Arabidopsis thaliana

• Genetic Interaction

interpreted the phenotypes of the mda1 rpl31 ... double mutants as additive: they displayed the phenotypic traits of parental individuals

Robles P, Micol JL, Quesada V - Mutations in the plant-conserved MTERF9 alter chloroplast gene expression, development and tolerance to abiotic stress in Arabidopsis thaliana

• Genetic Interaction

The phenotypes of the mterf9 rug2-2 ... double mutants were considered additive because they exhibited a combination of the parental phenotypes

Robles P, Micol JL, Quesada V - Mutations in the plant-conserved MTERF9 alter chloroplast gene expression, development and tolerance to abiotic stress in Arabidopsis thaliana

• Genetic Interaction

we considered the phenotype of the mda1-1 rpl24 ... double mutants to be synergistic (seedling growth was arrested early in development and individuals exhibited pale green expanded cotyledons and a first pair of tiny leaves

Robles P, Micol JL, Quesada V - Mutations in the plant-conserved MTERF9 alter chloroplast gene expression, development and tolerance to abiotic stress in Arabidopsis thaliana

• Genetic Interaction

Overexpression of the small leucine-zipper-type microProtein ZPR3, which largely reduces the activity of HD-ZIPIIIs, led to a further enhancement of the senescence phenotype, which was ameliorated in the wrky53 mutant background (supplementary material Fig. S3). This confirms that the senescence phenotype is mediated by deregulation of WRKY53 expression through HD-ZIPIIIs but also suggests that additional HD-ZIPIIIs are involved, as the senescence phenotype of 35S::ZPR3 plants is much stronger compared with rev5 mutants

Xie Y, Huhn K, Brandt R, Potschin M, Bieker S, Straub D, Doll J, Drechsler T, Zentgraf U, Wenkel S - REVOLUTA and WRKY53 connect early and late leaf development in Arabidopsis

• Genetic Interaction

the severe 35S::ZRP3-induced leaf phenotype is ameliorated in the wrky53 mutant background, suggesting that the action of other HD-ZIPIIIs involves WRKY53 also at early stages

Xie Y, Huhn K, Brandt R, Potschin M, Bieker S, Straub D, Doll J, Drechsler T, Zentgraf U, Wenkel S - REVOLUTA and WRKY53 connect early and late leaf development in Arabidopsis

• Genetic Interaction

introduction of a p35S:OSR2 construct into bri1-6 and bin2 could partially restore leaf and petiole growth, and the expansion defect in bri1-6 ... was partially restored by overexpression of OSR2

Qin Z, Zhang X, Zhang X, Feng G, Hu Y - The Arabidopsis ORGAN SIZE RELATED 2 is involved in regulation of cell expansion during organ growth

• Genetic Interaction

introduction of a p35S:OSR2 construct into bri1-6 and bin2 could partially restore leaf and petiole growth, and the expansion defect in ... bin2 leaf cells was partially restored by overexpression of OSR2

Qin Z, Zhang X, Zhang X, Feng G, Hu Y - The Arabidopsis ORGAN SIZE RELATED 2 is involved in regulation of cell expansion during organ growth

• Genetic Interaction

phb-1d mutation partially suppresses the stm mutant phenotype

McConnell JR, Barton MK - Leaf polarity and meristem formation in Arabidopsis

• Genetic Interaction

the an muta- tion and the clf mutation had an additive effect. These results suggest that the regulation by the CLF gene of the division and elongation of cells is independent of the polarity-specific regulation of the elongation of cells in leaves by the AN gene

Kim GT, Tsukaya H, Uchimiya H - The CURLY LEAF gene controls both division and elongation of cells during the expansion of the leaf blade in Arabidopsis thaliana

• Genetic Interaction

The synergistic effect of double mutations in pnh and ago1 demonstrate that these genes have overlapping functions

Lynn K, Fernandez A, Aida M, Sedbrook J, Tasaka M, Masson P, Barton MK - The PINHEAD/ZWILLE gene acts pleiotropically in Arabidopsis development and has overlapping functions with the ARGONAUTE1 gene